Difference between revisions of "Ampulla of Vater"
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
* | *Dependent on subtype. | ||
Notes: | |||
*May lack desmoplastic stroma.<ref>{{Ref Sternberg5|1640}}</ref> | |||
Main subtypes:<ref name=pmid15549428/> | |||
*Intestinal ampullary carcinoma. | |||
*Pancreatobiliary ampullary carcinoma. | |||
===IHC=== | |||
Features:<ref name=pmid15549428>{{Cite journal | last1 = Fischer | first1 = HP. | last2 = Zhou | first2 = H. | title = Pathogenesis of carcinoma of the papilla of Vater. | journal = J Hepatobiliary Pancreat Surg | volume = 11 | issue = 5 | pages = 301-9 | month = | year = 2004 | doi = 10.1007/s00534-004-0898-3 | PMID = 15549428 }}</ref> | |||
*CK7 +ve. | |||
*CK20 +ve. | |||
*MUC2 +ve. | |||
===Sign out=== | ===Sign out=== | ||
Revision as of 01:06, 13 September 2012
The Ampulla of Vater, also hepatopancreatic ampulla, is found in the duodenum.
Normal histology
Features:[1]
- +/-Pancreatic heterotopia - common.
- +/-Gastric heterotopia - not common.
Ampullary tumours
Ampullary adenoma
General
- Uncommon.
- May be associated with familial adenomatous polyposis (FAP).
Microscopic
Features:
- +/-Paneth cells - may be prominent.[2]
Ampullary carcinoma
General
- Uncommon.
- Textbook association: familial adenomatous polyposis.[3][4]
Microscopic
Features:
- Dependent on subtype.
Notes:
- May lack desmoplastic stroma.[5]
Main subtypes:[6]
- Intestinal ampullary carcinoma.
- Pancreatobiliary ampullary carcinoma.
IHC
Features:[6]
- CK7 +ve.
- CK20 +ve.
- MUC2 +ve.
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- Separate CAP protocol.
See also
References
- ↑ Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Reuter, Victor E; Stoler, Mark H (2009). Sternberg's Diagnostic Surgical Pathology (5th ed.). Lippincott Williams & Wilkins. pp. 1639. ISBN 978-0781779425.
- ↑ Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Reuter, Victor E; Stoler, Mark H (2009). Sternberg's Diagnostic Surgical Pathology (5th ed.). Lippincott Williams & Wilkins. pp. 1640. ISBN 978-0781779425.
- ↑ Tran, TC.; Vitale, GC. (Dec 2004). "Ampullary tumors: endoscopic versus operative management.". Surg Innov 11 (4): 255-63. PMID 15756395.
- ↑ Soravia, C.; Berk, T.; Haber, G.; Cohen, Z.; Gallinger, S.. "Management of advanced duodenal polyposis in familial adenomatous polyposis.". J Gastrointest Surg 1 (5): 474-8. PMID 9834381.
- ↑ Mills, Stacey E; Carter, Darryl; Greenson, Joel K; Reuter, Victor E; Stoler, Mark H (2009). Sternberg's Diagnostic Surgical Pathology (5th ed.). Lippincott Williams & Wilkins. pp. 1640. ISBN 978-0781779425.
- ↑ 6.0 6.1 Fischer, HP.; Zhou, H. (2004). "Pathogenesis of carcinoma of the papilla of Vater.". J Hepatobiliary Pancreat Surg 11 (5): 301-9. doi:10.1007/s00534-004-0898-3. PMID 15549428.