Difference between revisions of "Hemolytic uremic syndrome"
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'''Hemolytic uremic syndrome''', abbreviated '''HUS''', is the triad of:<ref>URL: [http://emedicine.medscape.com/article/779218-overview http://emedicine.medscape.com/article/779218-overview]. Accessed on: 8 September 2010.</ref> | '''Hemolytic uremic syndrome''', abbreviated '''HUS''', is the triad of:<ref>URL: [http://emedicine.medscape.com/article/779218-overview http://emedicine.medscape.com/article/779218-overview]. Accessed on: 8 September 2010.</ref> | ||
*Microangiopathic hemolytic anemia. | *Microangiopathic hemolytic anemia; microangiopathic<ref>URL: [http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm]. Accessed on: 9 September 2010.</ref> = disease affecting small blood vessels. | ||
*Thrombocytopenia. | *Thrombocytopenia; low platelet count. | ||
*Acute renal failure. | *Acute renal failure. | ||
==Etiology== | ==Etiology== | ||
*Verotoxins | *Rare (uncooked) hamburger. | ||
*''E. coli'' serotype O157:H7. | |||
**Verotoxins from ''E. coli'' O157:H7 --> endothelial injury.<ref name=pmid19180125>{{cite journal |author=Petruzziello TN, Mawji IA, Khan M, Marsden PA |title=Verotoxin biology: molecular events in vascular endothelial injury |journal=Kidney Int. Suppl. |volume= |issue=112 |pages=S17–9 |year=2009 |month=February |pmid=19180125 |doi=10.1038/ki.2008.612 |url=}}</ref> | |||
==Relation to thrombotic thrombocytopenic purpura (TTP)== | ==Relation to thrombotic thrombocytopenic purpura (TTP)== | ||
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**It is classically characterized by: microangiopathic hemolytic anemia, thrombocytopenia, fever, mild renal failure, and prominent neurologic symptoms. | **It is classically characterized by: microangiopathic hemolytic anemia, thrombocytopenia, fever, mild renal failure, and prominent neurologic symptoms. | ||
*Both are classified as ''thrombotic microangiopathies''.<ref>URL: [http://emedicine.medscape.com/article/779218-overview http://emedicine.medscape.com/article/779218-overview]. Accessed on: 8 September 2010.</ref> | *Both are classified as ''thrombotic microangiopathies''.<ref>URL: [http://emedicine.medscape.com/article/779218-overview http://emedicine.medscape.com/article/779218-overview]. Accessed on: 8 September 2010.</ref> | ||
==See also== | ==See also== | ||
Revision as of 19:38, 9 September 2010
Hemolytic uremic syndrome, abbreviated HUS, is the triad of:[1]
- Microangiopathic hemolytic anemia; microangiopathic[2] = disease affecting small blood vessels.
- Thrombocytopenia; low platelet count.
- Acute renal failure.
Etiology
- Rare (uncooked) hamburger.
- E. coli serotype O157:H7.
- Verotoxins from E. coli O157:H7 --> endothelial injury.[3]
Relation to thrombotic thrombocytopenic purpura (TTP)
- TTP is the main (clinical) DDx of HUS.
- It is classically characterized by: microangiopathic hemolytic anemia, thrombocytopenia, fever, mild renal failure, and prominent neurologic symptoms.
- Both are classified as thrombotic microangiopathies.[4]
See also
References
- ↑ URL: http://emedicine.medscape.com/article/779218-overview. Accessed on: 8 September 2010.
- ↑ URL: http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000005089.htm. Accessed on: 9 September 2010.
- ↑ Petruzziello TN, Mawji IA, Khan M, Marsden PA (February 2009). "Verotoxin biology: molecular events in vascular endothelial injury". Kidney Int. Suppl. (112): S17–9. doi:10.1038/ki.2008.612. PMID 19180125.
- ↑ URL: http://emedicine.medscape.com/article/779218-overview. Accessed on: 8 September 2010.