Difference between revisions of "Hemolytic uremic syndrome"

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'''Hemolytic uremic syndrome''' is the triad of:<ref>URL: [http://emedicine.medscape.com/article/779218-overview http://emedicine.medscape.com/article/779218-overview]. Accessed on: 8 September 2010.</ref>
'''Hemolytic uremic syndrome''', abbreviated '''HUS''', is the triad of:<ref>URL: [http://emedicine.medscape.com/article/779218-overview http://emedicine.medscape.com/article/779218-overview]. Accessed on: 8 September 2010.</ref>
*Microangiopathic hemolytic anemia.
*Microangiopathic hemolytic anemia.
*Thrombocytopenia.  
*Thrombocytopenia.  
*Acute renal failure.
*Acute renal failure.


==Big picture==
==Etiology==
Thrombotic microangiopathies:
*Verotoxins (from ''E. coli'' O157:H7) --> endothelial injury.<ref name=pmid19180125>{{cite journal |author=Petruzziello TN, Mawji IA, Khan M, Marsden PA |title=Verotoxin biology: molecular events in vascular endothelial injury |journal=Kidney Int. Suppl. |volume= |issue=112 |pages=S17–9 |year=2009 |month=February |pmid=19180125 |doi=10.1038/ki.2008.612 |url=}}</ref>
*Hemolytic uremic syndrome (HUS).
 
*Thrombotic thrombocytopenic purpura (TTP).
==Relation to thrombotic thrombocytopenic purpura (TTP)==
*TTP is the main (clinical) DDx of HUS.
**It is classically characterized by: microangiopathic hemolytic anemia, thrombocytopenia, fever, mild renal failure, and prominent neurologic symptoms.
*Both are classified as ''thrombotic microangiopathies''.<ref>URL: [http://emedicine.medscape.com/article/779218-overview http://emedicine.medscape.com/article/779218-overview]. Accessed on: 8 September 2010.</ref>


==Etiology==
==Etiology==
*Rare hamburger.
*Rare hamburger.
*E coli serotype O157:H7.
*E. coli serotype O157:H7.


==See also==
==See also==

Revision as of 19:35, 9 September 2010

Hemolytic uremic syndrome, abbreviated HUS, is the triad of:[1]

  • Microangiopathic hemolytic anemia.
  • Thrombocytopenia.
  • Acute renal failure.

Etiology

  • Verotoxins (from E. coli O157:H7) --> endothelial injury.[2]

Relation to thrombotic thrombocytopenic purpura (TTP)

  • TTP is the main (clinical) DDx of HUS.
    • It is classically characterized by: microangiopathic hemolytic anemia, thrombocytopenia, fever, mild renal failure, and prominent neurologic symptoms.
  • Both are classified as thrombotic microangiopathies.[3]

Etiology

  • Rare hamburger.
  • E. coli serotype O157:H7.

See also

References

  1. ↑ URL: http://emedicine.medscape.com/article/779218-overview. Accessed on: 8 September 2010.
  2. ↑ Petruzziello TN, Mawji IA, Khan M, Marsden PA (February 2009). "Verotoxin biology: molecular events in vascular endothelial injury". Kidney Int. Suppl. (112): S17–9. doi:10.1038/ki.2008.612. PMID 19180125.
  3. ↑ URL: http://emedicine.medscape.com/article/779218-overview. Accessed on: 8 September 2010.
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