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Difference between revisions of "Granular cell tumour"
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+EM
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Features: | Features: | ||
*Cells with abundant eosinophilic granular cytoplasm - '''key feature'''. | *Cells with abundant eosinophilic granular cytoplasm - '''key feature'''. | ||
**Granules: | **Granules (represent abundant lysosomes<ref name=pmid10410172/>): | ||
***Size: 1-3 micrometers. | ***Size: 1-3 micrometers. | ||
***Poorly demarcated. | ***Poorly demarcated (on light microscopy). | ||
*Nested architecture. | *Nested architecture. | ||
*+/-Pseudoepitheliomatous hyperplasia. | *+/-Pseudoepitheliomatous hyperplasia. | ||
| Line 54: | Line 54: | ||
*CD68 +ve (cytoplasmic). | *CD68 +ve (cytoplasmic). | ||
*Vimentin +ve (membranous). | *Vimentin +ve (membranous). | ||
*Calretinin +ve (90-95%).<ref name=pmid12579997>{{Cite journal | last1 = Fine | first1 = SW. | last2 = Li | first2 = M. | title = Expression of calretinin and the alpha-subunit of inhibin in granular cell tumors. | journal = Am J Clin Pathol | volume = 119 | issue = 2 | pages = 259-64 | month = Feb | year = 2003 | doi = 10.1309/GRH4-JWX6-J9J7-QQTA | PMID = 12579997 }} | *Calretinin +ve (90-95%).<ref name=pmid12579997>{{Cite journal | last1 = Fine | first1 = SW. | last2 = Li | first2 = M. | title = Expression of calretinin and the alpha-subunit of inhibin in granular cell tumors. | journal = Am J Clin Pathol | volume = 119 | issue = 2 | pages = 259-64 | month = Feb | year = 2003 | doi = 10.1309/GRH4-JWX6-J9J7-QQTA | PMID = 12579997 }}</ref> | ||
</ref> | |||
Images: | Images: | ||
*[http://commons.wikimedia.org/wiki/File:Granular_cell_tumor_(3)_skin.jpg GCT - skin (WC)]. | *[http://commons.wikimedia.org/wiki/File:Granular_cell_tumor_(3)_skin.jpg GCT - skin (WC)]. | ||
*[http://commons.wikimedia.org/wiki/File:Granular_cell_tumor_(4)_S-100.JPG GCT - S100 (WC)]. | *[http://commons.wikimedia.org/wiki/File:Granular_cell_tumor_(4)_S-100.JPG GCT - S100 (WC)]. | ||
==EM== | |||
*Abundant lysosomes.<ref name=pmid10410172>{{Cite journal | last1 = Ordóñez | first1 = NG. | title = Granular cell tumor: a review and update. | journal = Adv Anat Pathol | volume = 6 | issue = 4 | pages = 186-203 | month = Jul | year = 1999 | doi = | PMID = 10410172 }}</ref> | |||
==See also== | ==See also== | ||