Difference between revisions of "Burkitt lymphoma"
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'''Burkitt lymphoma''', abbreviated '''BL''', is an uncommon | '''Burkitt lymphoma''', abbreviated '''BL''', is an uncommon [[lymphoma]] with medium-sized cells. | ||
==General== | ==General== | ||
| Line 16: | Line 16: | ||
==Pathophysiology== | ==Pathophysiology== | ||
*Origin cell: germinal centre B cells (favoured) vs. memory B cells.<ref name=pmid12610094/> | *Origin cell: germinal centre B cells (favoured) vs. memory B cells.<ref name=pmid12610094/> | ||
==Microscopic== | ==Microscopic== | ||
| Line 35: | Line 31: | ||
Image: [http://en.wikipedia.org/wiki/File:Burkitt_lymphoma,_H%26E.jpg Starry-sky pattern - Ed Uthman (WC)]. | Image: [http://en.wikipedia.org/wiki/File:Burkitt_lymphoma,_H%26E.jpg Starry-sky pattern - Ed Uthman (WC)]. | ||
==IHC== | |||
Features: | |||
*CD20 +ve. | |||
*CD10 +ve. | |||
*BCL6 +ve. | |||
*EBER +ve. | |||
Others: | |||
*BCL2 -ve. | |||
==Cytologic definition== | |||
*t(8;14) (q24;q32) translocation + a few variants or c-myc rearrangement.<ref name=pmid12610094/> | |||
==See also== | ==See also== | ||
Revision as of 19:45, 17 August 2010
Burkitt lymphoma, abbreviated BL, is an uncommon lymphoma with medium-sized cells.
General
- Extremely high proliferative rate & rate of apoptosis.
Subtypes
- Three subtypes recognized:[1]
- Endemic:
- Found in Africa.
- EBV (Epstein-Barr virus) associated.[1]
- Non-endemic:
- Typical of the BL seen in the western world; EBV negative.
- Immunodeficiency associated:
- Associated with HIV infection.
Pathophysiology
- Origin cell: germinal centre B cells (favoured) vs. memory B cells.[1]
Microscopic
Features:
- "Starry-sky pattern".
- The stars in the pattern are: tingible-bodies laden macrophages.
- Tingible-bodies macrophages = macrophages containing dead body of apoptotic tumor cells.
- The tumour cells are the sky.
- The stars in the pattern are: tingible-bodies laden macrophages.
- Tumour cells:[1]
- Medium size cells (~1.5-2x the size of a RBC) with uniform size ("monotonous") -- key feature.
- Round nuclei.
- Small nucleolus.
- Relatively abundant cytoplasm.
- Brisk mitotic rate.
Image: Starry-sky pattern - Ed Uthman (WC).
IHC
Features:
- CD20 +ve.
- CD10 +ve.
- BCL6 +ve.
- EBER +ve.
Others:
- BCL2 -ve.
Cytologic definition
- t(8;14) (q24;q32) translocation + a few variants or c-myc rearrangement.[1]