Difference between revisions of "Basal cell adenocarcinoma"

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#redirect [[Salivary_glands#Basal_cell_adenocarcinoma]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Basal_cell_adenocarcinoma_-_2_-_parotid_gland_-_high_mag.jpg
| Width      =
| Caption    = Basal cell adenocarcinoma. [[H&E stain]].
| Micro      = unencapsulated lesion with basal-like cells, tubular component - within basal component, dense hyaline stroma around tumour cells
| Subtypes  =
| LMDDx      = [[adenoid cystic carcinoma]], [[basal cell adenoma]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[salivary gland]] - usu. parotid gland
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence =
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    =
}}
'''Basal cell adenocarcinoma''', abbreviated ''BCAC'', is an uncommon malignant [[salivary gland]] tumour.
 
It should ''not'' be confused with ''[[basal cell carcinoma]]'', a very common tumour of the skin.
===General===
*Very rare.
*Malignant.
*Good prognosis.
*May arise from a ''[[basal cell adenoma]]''.<ref name=pmid8952553/>
 
===Gross===
*Usually in the parotid gland ~90% of cases.<ref name=pmid8952553>{{Cite journal  | last1 = Muller | first1 = S. | last2 = Barnes | first2 = L. | title = Basal cell adenocarcinoma of the salivary glands. Report of seven cases and review of the literature. | journal = Cancer | volume = 78 | issue = 12 | pages = 2471-7 | month = Dec | year = 1996 | doi =  | PMID = 8952553 }}</ref>
 
===Microscopic===
Features:
#Lesion is '''not''' encapsulated - '''key feature'''.
#Basal-like cells:
#*Basophilic cells - '''key feature'''.
#*Usually in nests.
#**May be bilayered tubules ''or'' [[trabeculae]].
#*Large basophilic nucleus.
#*Minimal-to-moderate eosinophilic cytoplasm.
#Stromal cells.
#*Plump spindle cells without significant nuclear atypia.
#**Stromal cell nuclei width ~= diameter [[RBC]].
#*Dense hyaline stroma.
#Tubular component.
#*Within basal component, may be minimal.
 
DDx:
*[[Adenoid cystic carcinoma]].
*[[Basal cell adenoma]] - encapsulated.
*Basaloid [[squamous cell carcinoma]].
 
===Images===
<gallery>
Image:Basal_cell_adenocarcinoma_-_parotid_gland_-_intermed_mag.jpg | BCAC - intermed. mag. (WC/Nephron)
Image:Basal_cell_adenocarcinoma_-_parotid_gland_-_high_mag.jpg | BCAC - high mag. (WC/Nephron)
Image:Basal_cell_adenocarcinoma_-_2_-_parotid_gland_-_high_mag.jpg | BCAC - high mag. (WC/Nephron)
</gallery>
www:
*[http://www.webpathology.com/image.asp?n=5&Case=115 Basal cell adenocarcinoma - intermed. mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=6&Case=115 Basal cell adenocarcinoma - high mag. (webpathology.com)].
 
==IHC==
Features:<ref name=pmid17922602>{{Cite journal  | last1 = Farrell | first1 = T. | last2 = Chang | first2 = YL. | title = Basal cell adenocarcinoma of minor salivary glands. | journal = Arch Pathol Lab Med | volume = 131 | issue = 10 | pages = 1602-4 | month = Oct | year = 2007 | doi = 10.1043/1543-2165(2007)131[1602:BCAOMS]2.0.CO;2 | PMID = 17922602 }}</ref>
*CK7 +ve (strong).
*S100 +ve/-ve.
 
==See also==
*[[Salivary glands]].
*[[Head and neck pathology]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Salivary gland]]
[[Category:Head and neck pathology]]

Revision as of 13:21, 30 July 2013

Basal cell adenocarcinoma
Diagnosis in short

Basal cell adenocarcinoma. H&E stain.
LM unencapsulated lesion with basal-like cells, tubular component - within basal component, dense hyaline stroma around tumour cells
LM DDx adenoid cystic carcinoma, basal cell adenoma
Site salivary gland - usu. parotid gland

Basal cell adenocarcinoma, abbreviated BCAC, is an uncommon malignant salivary gland tumour.

It should not be confused with basal cell carcinoma, a very common tumour of the skin.

General

Gross

  • Usually in the parotid gland ~90% of cases.[1]

Microscopic

Features:

  1. Lesion is not encapsulated - key feature.
  2. Basal-like cells:
    • Basophilic cells - key feature.
    • Usually in nests.
    • Large basophilic nucleus.
    • Minimal-to-moderate eosinophilic cytoplasm.
  3. Stromal cells.
    • Plump spindle cells without significant nuclear atypia.
      • Stromal cell nuclei width ~= diameter RBC.
    • Dense hyaline stroma.
  4. Tubular component.
    • Within basal component, may be minimal.

DDx:

Images

  • BCAC - intermed. mag. (WC/Nephron)

  • BCAC - high mag. (WC/Nephron)

  • BCAC - high mag. (WC/Nephron)

www:

IHC

Features:[2]

  • CK7 +ve (strong).
  • S100 +ve/-ve.

See also

References

  1. ↑ 1.0 1.1 Muller, S.; Barnes, L. (Dec 1996). "Basal cell adenocarcinoma of the salivary glands. Report of seven cases and review of the literature.". Cancer 78 (12): 2471-7. PMID 8952553.
  2. ↑ Farrell, T.; Chang, YL. (Oct 2007). "Basal cell adenocarcinoma of minor salivary glands.". Arch Pathol Lab Med 131 (10): 1602-4. doi:10.1043/1543-2165(2007)131[1602:BCAOMS]2.0.CO;2. PMID 17922602.
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