Difference between revisions of "Extramammary Paget disease"
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*Classically seen in the [[vulva]]. | *Classically seen in the [[vulva]]. | ||
*May afflict penis.<ref name=pmid19126202>{{Cite journal | last1 = Ekwueme | first1 = KC. | last2 = Zakhour | first2 = HD. | last3 = Parr | first3 = NJ. | title = Extramammary Paget's disease of the penis: a case report and review of the literature. | journal = J Med Case Reports | volume = 3 | issue = | pages = 4 | month = | year = 2009 | doi = 10.1186/1752-1947-3-4 | PMID = 19126202 }}</ref> | *May afflict penis.<ref name=pmid19126202>{{Cite journal | last1 = Ekwueme | first1 = KC. | last2 = Zakhour | first2 = HD. | last3 = Parr | first3 = NJ. | title = Extramammary Paget's disease of the penis: a case report and review of the literature. | journal = J Med Case Reports | volume = 3 | issue = | pages = 4 | month = | year = 2009 | doi = 10.1186/1752-1947-3-4 | PMID = 19126202 }}</ref> | ||
Clinical: | |||
*Pruritis. | |||
===Microscopic=== | ===Microscopic=== | ||
Revision as of 02:48, 14 November 2012
Extramammary Paget disease, abbreviated EMPD, is a skin disease. As the name suggests, there is also a Paget disease of the breast.
There is also a Paget disease of the bone - just to make things confusing. This is dealt with in the bone article and has nothing (from a pathologic perspective) to do with the Paget disease discussed in this article
General
- Usually not associated with malignancy, unlike the Paget disease of the breast - important difference.
- Classically seen in the vulva.
- May afflict penis.[1]
Clinical:
- Pruritis.
Microscopic
Features:
- Epitheliod morphology (round/ovoid).
- Cells nested or single.
- Clear/pale cytoplasm key feature - may also be eosinophilic.
- Large nucleoli.
Images:
DDx
- Benign Toker cell hyperplasia.
- Malignant melanoma.
- Bowen disease.
- Apocrine carcinoma of the skin.[2]
IHC
Panel:
- CEA +ve (-ve in Bowen's disease, -ve in Toker cells).
- CK7 +ve. (???)
- Toker cells CK7 +ve.[3]
- S100 -ve, HMB-45 -ve (both typically +ve in melanoma).
Additional:
- HER2/neu - usually +ve.
- CK5/6 -ve.[4]
- Usu. +ve in squamous cell carcinoma.
See also
References
- ↑ Ekwueme, KC.; Zakhour, HD.; Parr, NJ. (2009). "Extramammary Paget's disease of the penis: a case report and review of the literature.". J Med Case Reports 3: 4. doi:10.1186/1752-1947-3-4. PMID 19126202.
- ↑ URL: http://derm101.com/searchResults.aspx?searchStr=apocrine+carcinoma&rootTerm=apocrine+carcinoma&searchType=2&rootID=12687. Accessed on: 9 September 2011.
- ↑ Nofech-Mozes, S.; Hanna, W.. "Toker cells revisited.". Breast J 15 (4): 394-8. doi:10.1111/j.1524-4741.2009.00743.x. PMID 19601945.
- ↑ RS. May 2010.