Difference between revisions of "Serrated polyposis syndrome"
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'''Serrated polyposis syndrome''', previously known as '''hyperplastic polyposis syndrome''', is an uncommon condition characterized by the presence of (colonic) [[hyperplastic polyp]]s, | '''Serrated polyposis syndrome''', previously known as '''hyperplastic polyposis syndrome''', is an uncommon condition characterized by the presence of serrated (colonic) polyps ([[hyperplastic polyp]]s, [[sessile serrated adenoma]]s), probably represents several distinct pathologies and is associated with an increased risk of [[colorectal carcinoma]].<ref name=pmid21045813>{{Cite journal | last1 = Huang | first1 = CS. | last2 = Farraye | first2 = FA. | last3 = Yang | first3 = S. | last4 = O'Brien | first4 = MJ. | title = The clinical significance of serrated polyps. | journal = Am J Gastroenterol | volume = 106 | issue = 2 | pages = 229-40; quiz 241 | month = Feb | year = 2011 | doi = 10.1038/ajg.2010.429 | PMID = 21045813 | URL = http://www.nature.com/ajg/journal/v106/n2/full/ajg2010429a.html }}</ref> | ||
==WHO definition== | ==WHO definition== | ||
Revision as of 14:01, 25 January 2012
Serrated polyposis syndrome, previously known as hyperplastic polyposis syndrome, is an uncommon condition characterized by the presence of serrated (colonic) polyps (hyperplastic polyps, sessile serrated adenomas), probably represents several distinct pathologies and is associated with an increased risk of colorectal carcinoma.[1]
WHO definition
One of the following three:[2]
- >=Five hyperplastic polyps proximal to the sigmoid colon with two of the five >=10 mm.
- One hyperplastic polyp proximal to the sigmoid colon, in someone with a first degree relative with the syndrome.
- >20 hyperplastic polyps through-out the colon, i.e. not all can be rectal polyps.
- One source suggests it ought to be >=30 HPs.[1]
See also
References
- ↑ 1.0 1.1 Huang, CS.; Farraye, FA.; Yang, S.; O'Brien, MJ. (Feb 2011). "The clinical significance of serrated polyps.". Am J Gastroenterol 106 (2): 229-40; quiz 241. doi:10.1038/ajg.2010.429. PMID 21045813.
- ↑ Rosty, C.; Parry, S.; Young, JP. (2011). "Serrated polyposis: an enigmatic model of colorectal cancer predisposition.". Patholog Res Int 2011: 157073. doi:10.4061/2011/157073. PMID 21660283.