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Difference between revisions of "Adrenal gland"
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*[http://commons.wikimedia.org/wiki/File:Carotid_body_tumour_2_low_mag.jpg Carotid body tumour - low mag. (WC)]. | *[http://commons.wikimedia.org/wiki/File:Carotid_body_tumour_2_low_mag.jpg Carotid body tumour - low mag. (WC)]. | ||
*[http://commons.wikimedia.org/wiki/File:Carotid_body_tumour_2_high_mag.jpg Carotid body tumour - high mag. (WC)]. | *[http://commons.wikimedia.org/wiki/File:Carotid_body_tumour_2_high_mag.jpg Carotid body tumour - high mag. (WC)]. | ||
====Malignant pheochromoctyoma==== | |||
#''Robbins'' says metastases are the sole criteria of malignancy.<ref name=Ref_PCPBoD8_586>{{Ref PCPBoD8|586}}</ref> | |||
#''Thompson'' suggests one can differentiate benign from malignant with the aid of the following:<ref name=Ref_EP259>{{Ref EP|259}}</ref> | |||
#*Marked nuclear atypia. | |||
#*Invasion: | |||
#**Capsular. | |||
#**Vascular. | |||
#*Necrosis. | |||
#*Cellular monotony. | |||
#*Mitoses: | |||
#**Rate. | |||
#**Atypical mitosis. | |||
===IHC=== | ===IHC=== | ||
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*S100 -ve. | *S100 -ve. | ||
**Pheochromocytoma +ve (sustentacular cells).<ref>{{cite journal |author=Unger P, Hoffman K, Pertsemlidis D, Thung S, Wolfe D, Kaneko M |title=S100 protein-positive sustentacular cells in malignant and locally aggressive adrenal pheochromocytomas |journal=Arch. Pathol. Lab. Med. |volume=115 |issue=5 |pages=484–7 |year=1991 |month=May |pmid=1673596 |doi= |url=}}</ref> | **Pheochromocytoma +ve (sustentacular cells).<ref>{{cite journal |author=Unger P, Hoffman K, Pertsemlidis D, Thung S, Wolfe D, Kaneko M |title=S100 protein-positive sustentacular cells in malignant and locally aggressive adrenal pheochromocytomas |journal=Arch. Pathol. Lab. Med. |volume=115 |issue=5 |pages=484–7 |year=1991 |month=May |pmid=1673596 |doi= |url=}}</ref> | ||
==Neuroblastoma== | ==Neuroblastoma== | ||