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Difference between revisions of "Fibroblastic/myofibroblastic tumours"
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Fibroblastic/myofibroblastic tumours (view source)
Revision as of 14:55, 8 October 2011
, 14:55, 8 October 2011→See also: more
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**Gene fusion ETV6-NTRK3. | **Gene fusion ETV6-NTRK3. | ||
***Same translocation in [[mesoblastic nephroma]]. | ***Same translocation in [[mesoblastic nephroma]]. | ||
==Myxofibrosarcoma== | |||
*Should '''not''' be confused with ''[[low-grade fibromyxoid sarcoma]]''.<ref name=pmid8650138>{{Cite journal | last1 = Mentzel | first1 = T. | last2 = Katenkamp | first2 = D. | last3 = Fletcher | first3 = CD. | title = [Low malignancy myxofibrosarcoma versus low malignancy fibromyxoid sarcoma. Distinct entities with similar names but different clinical course]. | journal = Pathologe | volume = 17 | issue = 2 | pages = 116-21 | month = Mar | year = 1996 | doi = | PMID = 8650138 }}</ref> | |||
===General=== | |||
*Malignant. | |||
*Usu. older people, superficial (skin/dermis) and extremities (arm, legs).<ref name=Ref_WMSP612-3>{{Ref WMSP|612-3}}</ref><ref name=pmid17197925/> | |||
===Microscopic=== | |||
Features:<ref name=Ref_WMSP612-3>{{Ref WMSP|612-3}}</ref> | |||
*Discontinuous fibrous septae. | |||
*Myxoid background. | |||
*Variable cellularity and nuclear pleomorphism. | |||
*Spindle cells or epithelioid cells.<ref name=pmid17197925/> | |||
*Curvilinear vessels.<ref name=pmid17197925>{{Cite journal | last1 = Nascimento | first1 = AF. | last2 = Bertoni | first2 = F. | last3 = Fletcher | first3 = CD. | title = Epithelioid variant of myxofibrosarcoma: expanding the clinicomorphologic spectrum of myxofibrosarcoma in a series of 17 cases. | journal = Am J Surg Pathol | volume = 31 | issue = 1 | pages = 99-105 | month = Jan | year = 2007 | doi = 10.1097/01.pas.0000213379.94547.e7 | PMID = 17197925 }}</ref> | |||
DDx: | |||
*[[Liposarcoma|Myxoid liposarcoma]]. | |||
*[[Low-grade fibromyxoid sarcoma]] - alternating fibrous and myxoid areas.<ref name=pmid8650138/> | |||
==See also== | ==See also== | ||