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Difference between revisions of "Salivary glands"
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→Polymorphous low-grade adenocarcinoma
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==Polymorphous low-grade adenocarcinoma== | ==Polymorphous low-grade adenocarcinoma== | ||
*Classically found in the palate. | *Abbreviated ''PLGA''. | ||
===General=== | |||
*Almost exclusively in the oral cavity. | |||
**Classically found in the palate -- 60% of PLGAs in palate. | |||
*Tumour of the minor salivary glands. | *Tumour of the minor salivary glands. | ||
*Always a low-grade tumour - by definition. | |||
*Female:male ~= 2:1. | |||
*Older people ~50-70 years old. | |||
===Microscopy=== | ===Microscopy=== | ||
Features: | |||
*Cytologically monotonous (uniform) with variable architecture - '''key feature'''. | *Cytologically monotonous (uniform) with variable architecture - '''key feature'''. | ||
**Architecture: often small nests, may be targetoid. | **Architecture: often small nests, may be targetoid. | ||
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*Eosinophilic cytoplasm. | *Eosinophilic cytoplasm. | ||
DDx: | |||
*Adenoid cystic carcinoma. | |||
*Pleomorphic adenoma. | *Pleomorphic adenoma. | ||
* | |||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Polymorphous_low-grade_adenocarcinoma_-_very_low_mag.jpg PLGA - very low mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Polymorphous_low-grade_adenocarcinoma_high_mag.jpg PLGA - high mag. (WC)]. | |||
===IHC=== | |||
*S100 +ve, CK +ve, vimentin +ve. | |||
*GFAP +ve/-ve. | |||
*BCL2 +ve/-ve. | |||
*Generally negative for myoepithelial markers (calponin, actin) - '''useful if negative'''. | |||
==Carcinoma ex pleomorphic adenoma== | ==Carcinoma ex pleomorphic adenoma== | ||