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Difference between revisions of "Esophagus"
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→Columnar dysplasia
(→Tabular summary: more) |
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=Neoplastic= | =Neoplastic= | ||
==Columnar dysplasia== | ==Columnar dysplasia== | ||
===Classification=== | ===General=== | ||
====Classification==== | |||
*Indefinite for dysplasia. | *Indefinite for dysplasia. | ||
**Diagnose used in the context of uncertainty (like ''[[gynecologic cytopathology|ASCUS]]'' and ''[[prostate gland|ASAP]]''); usually used in the context of inflammation. | **Diagnose used in the context of uncertainty (like ''[[gynecologic cytopathology|ASCUS]]'' and ''[[prostate gland|ASAP]]''); usually used in the context of inflammation. | ||
| Line 338: | Line 340: | ||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features to assess:<ref>{{Ref GI|46}}</ref> | ||
# | # Lack of surface maturation. | ||
#* | #*Lack of lighter staining at surface. | ||
#*Nuclear crowding. | #*Nuclear crowding at surface. | ||
#* | #*Nuclei at the surface not smaller. | ||
# | # Architecture - esp. at low power. | ||
#* | #* Glands not round. | ||
#** Low-grade feature: gland budding. | |||
#** High-grade features: cribriforming, cystic dilation, necrotic debris. | |||
#* Gland density: | |||
#** Increased & round - think low-grade dysplasia. | |||
#** Increased & irregular - think high-grade dysplasia. | |||
# Cytology, esp. at high magnification. | |||
#* Nuclear abnormalities in: size, staining, shape. | |||
#* Loss of "nuclear polarity" = high-grade feature | |||
#** Loss of palisaded appearance, rounding-up of nuclei. | |||
# Inflammation, erosions & ulceration. | |||
#* Marked inflammation should prompt consideration of knocking down the diagnosis one step, i.e. low-grade becomes indefinite ''or'' high-grade becomes low-grade. | |||
Negatives: | Negatives: | ||