Difference between revisions of "Soft tissue lesions"
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(→Angiosarcoma: +IHC) |
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==Angiosarcoma== | ==Angiosarcoma== | ||
===General=== | ===General=== | ||
*Malignant tumour. | *Malignant tumour - with a horrible prognosis.<ref name=pmid20537949>{{cite journal |author=Young RJ, Brown NJ, Reed MW, Hughes D, Woll PJ |title=Angiosarcoma |journal=Lancet Oncol |volume= |issue= |pages= |year=2010 |month=May |pmid=20537949 |doi=10.1016/S1470-2045(10)70023-1 |url=}}</ref> | ||
*Classically on the scalp or head & neck. | |||
*May arise secondary to therapeutic radiation or chronic lymphoedema related to breast carcinoma. | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Very many small capillaries | *Very many small capillaries of irregular shape lined with: | ||
** | **Pleomorphic nuclei. | ||
***May have hobnail morphology. | |||
*Mitoses. | *Mitoses. | ||
*Cytoplasmic vacuoles. | *Cytoplasmic vacuoles. | ||
**Cells trying to form lumina - embryologic. | **Cells trying to form lumina - embryologic. | ||
Notes: | |||
*Epithelioid variant (with abundant cytoplasm & sheeting architecture) may resemble ''melanoma'' or ''hepatocellular carcinoma''. | |||
===IHC=== | |||
*CD34 +ve. | |||
*D2-40 +ve. (???) | |||
*CD31 +ve. | |||
==Hemangioendothelioma== | ==Hemangioendothelioma== | ||