Difference between revisions of "Salivary glands"

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Retrieved from "https://librepathology.org/wiki/Salivary_glands"

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 ===Microscopic===
 Features:
-*Basophilic cells.
+#Basal component.
-*Usu. nests; may be bilayered tubules ''or'' [[trabeculae]].
+#*Basophilic cells - '''key feature'''.
+#*Usu. in nests.
+#**May be bilayered tubules ''or'' [[trabeculae]].
+#*Large basophilic nucleus.
+#*Minimal-to-moderate eosinophilic cytoplasm.
+#Stromal cells.
+#*Plump spindle cells without significant nuclear atypia - '''distinguishing feature'''.
+#*Dense hyaline stroma.
+#Tubular component.
+#*Within basal component, may be minimal.
+#Lesion is encapsulated.
 Notes:
 *No chondromyxoid stroma.
-**Chondromyxoid stroma present -> pleomorphic adenoma.
+**Chondromyxoid stroma present -> [[pleomorphic adenoma]].
-*Neoplastic cells embeded in stroma ("stromal invasion") = basal cell adenocarcinoma.
+*Neoplastic cells embedded in stroma ("stromal invasion") = basal cell adenocarcinoma.
 **Basal cell adenocarcinoma may be cytologically indistinguishable from basal cell adenoma, i.e. "bad" architecture makes it a basal cell adenocarcinoma.
+DDx:
+*[[Adenoid cystic carcinoma]].
+**Not encapsulated.
+*[[Canalicular adenoma]].
+**Different site - CA in oral cavity, usu. upper lip.
+Images:
+*[http://moon.ouhsc.edu/kfung/jty1/Com/ComImage/Com304-3-LM1.gif BCA (ouhsc.edu)].<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/Com/Com304-3-Diss.htm http://moon.ouhsc.edu/kfung/jty1/Com/Com304-3-Diss.htm]. Accessed on: 25 October 2011.</ref>
+*[http://www.webpathology.com/image.asp?n=4&Case=115 BCA (webpathology.com)].
 ===IHC===
 *Luminal stains +ve: CK7 +ve, CAM5.2 +ve.
+*p63 +ve -- basal component.
+*S100 +ve -- spindle cells in the stroma.
 ==Canalicular adenoma==

Difference between revisions of "Salivary glands"

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