Difference between revisions of "Dermal cylindroma"

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#~~redirect~~ [[Dermatologic neoplasms~~#Dermal_cylindroma~~]]

'''Dermal cylindroma''' is a benign skin lesion classically seen on the scalp.

It should '''not''' be confused with ''cylindroma'' ([[adenoid cystic carcinoma]]).

==General==

*Benign skin lesion.

**Occasionally malignant.<ref name=pmid16882695/>

*May be related to ''[[eccrine spiradenoma]]''.<ref name=pmid6302142>{{Cite journal | last1 = Gerber | first1 = JE. | last2 = Descalzi | first2 = ME. | title = Eccrine spiradenoma and dermal cylindroma. | journal = J Cutan Pathol | volume = 10 | issue = 1 | pages = 73-8 | month = Feb | year = 1983 | doi = | PMID = 6302142 }}</ref><ref name=pmid8936072>{{Cite journal | last1 = Lee | first1 = MW. | last2 = Kelly | first2 = JW. | title = Dermal cylindroma and eccrine spiradenoma. | journal = Australas J Dermatol | volume = 37 | issue = 1 | pages = 48-9 | month = Feb | year = 1996 | doi = | PMID = 8936072 }}</ref>

May be familial:<ref name=pmid16882695/>

*Familial cylindromatosis (autosomal dominant).

*Brook–Spiegler syndrome.

==Gross==

*Classically scalp - usually head and neck or face.

==Microscopic==

Features:<ref name=pmid16882695/>

*Nests of cells that fit together like a jigsaw puzzle - the borders of the nests are opposed and undulate.

*#Basaloid cells with scant cytoplasm and dark nuclei palisade around the edge of the nests.

*#Larger cells with moderate eosinophilic cytoplasm and lighter staining nuclei are at the centre of the nests.

*Cells nests surrounded by a band of hyaline (i.e. glassy, eosinophilic, acellular) material ~ 2X thickness of a basilar cell - '''key feature'''.

**This is basement membrane.

DDx:

*[[Eccrine spiradenoma]].

*[[Basal cell carcinoma]] - has [[myxoid stroma]].

===Images===

Image:Dermal_cylindroma_intermed_mag.jpg | Dermal cylindroma. (WC/Nephron)

Image:Dermal_cylindroma_intermed_mag_deep.jpg | Dermal cylindroma - high mag. (WC/Nephron)

</gallery>

www:

*[http://jcp.bmj.com/content/60/2/145/F7.large.jpg Dermal cylindroma (bmj.com)].<ref name=pmid16882695>{{Cite journal | last1 = Obaidat | first1 = NA. | last2 = Alsaad | first2 = KO. | last3 = Ghazarian | first3 = D. | title = Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat glands. | journal = J Clin Pathol | volume = 60 | issue = 2 | pages = 145-59 | month = Feb | year = 2007 | doi = 10.1136/jcp.2006.041608 | PMID = 16882695 | PMC = 1860616 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860616/?tool=pubmed }}</ref>

==Stains==

*PAS +ve (basement membrane).<ref name=pmid16882695/>

==See also==

*[[Dermatologic neoplasms]].

==References==

[[Category:Diagnosis]]

[[Category:Dermatologic neoplasms]]

Difference between revisions of "Dermal cylindroma"

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@@ Line 1: / Line 1: @@
-#redirect [[Dermatologic neoplasms#Dermal_cylindroma]]
+'''Dermal cylindroma''' is a benign skin lesion classically seen on the scalp.
+It should '''not''' be confused with ''cylindroma'' ([[adenoid cystic carcinoma]]).
+==General==
+*Benign skin lesion.
+**Occasionally malignant.<ref name=pmid16882695/>
+*May be related to ''[[eccrine spiradenoma]]''.<ref name=pmid6302142>{{Cite journal  | last1 = Gerber | first1 = JE. | last2 = Descalzi | first2 = ME. | title = Eccrine spiradenoma and dermal cylindroma. | journal = J Cutan Pathol | volume = 10 | issue = 1 | pages = 73-8 | month = Feb | year = 1983 | doi =  | PMID = 6302142 }}</ref><ref name=pmid8936072>{{Cite journal  | last1 = Lee | first1 = MW. | last2 = Kelly | first2 = JW. | title = Dermal cylindroma and eccrine spiradenoma. | journal = Australas J Dermatol | volume = 37 | issue = 1 | pages = 48-9 | month = Feb | year = 1996 | doi =  | PMID = 8936072 }}</ref>
+May be familial:<ref name=pmid16882695/>
+*Familial cylindromatosis (autosomal dominant).
+*Brook–Spiegler syndrome.
+==Gross==
+*Classically scalp - usually head and neck or face.
+==Microscopic==
+Features:<ref name=pmid16882695/>
+*Nests of cells that fit together like a jigsaw puzzle - the borders of the nests are opposed and undulate.
+*#Basaloid cells with scant cytoplasm and dark nuclei palisade around the edge of the nests.
+*#Larger cells with moderate eosinophilic cytoplasm and lighter staining nuclei are at the centre of the nests.
+*Cells nests surrounded by a band of hyaline (i.e. glassy, eosinophilic, acellular) material ~ 2X thickness of a basilar cell - '''key feature'''.
+**This is basement membrane.
+DDx:
+*[[Eccrine spiradenoma]].
+*[[Basal cell carcinoma]] - has [[myxoid stroma]].
+===Images===
+<gallery>
+Image:Dermal_cylindroma_intermed_mag.jpg | Dermal cylindroma. (WC/Nephron)
+Image:Dermal_cylindroma_intermed_mag_deep.jpg | Dermal cylindroma - high mag. (WC/Nephron)
+</gallery>
+www:
+*[http://jcp.bmj.com/content/60/2/145/F7.large.jpg Dermal cylindroma (bmj.com)].<ref name=pmid16882695>{{Cite journal  | last1 = Obaidat | first1 = NA. | last2 = Alsaad | first2 = KO. | last3 = Ghazarian | first3 = D. | title = Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat glands. | journal = J Clin Pathol | volume = 60 | issue = 2 | pages = 145-59 | month = Feb | year = 2007 | doi = 10.1136/jcp.2006.041608 | PMID = 16882695 | PMC = 1860616 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860616/?tool=pubmed }}</ref>
+==Stains==
+*PAS +ve (basement membrane).<ref name=pmid16882695/>
+==See also==
+*[[Dermatologic neoplasms]].
+==References==
+{{Reflist|2}}
 [[Category:Diagnosis]]
+[[Category:Dermatologic neoplasms]]