Difference between revisions of "Neurodegenerative diseases"

Line 352:

=Other=

==Chronic traumatic encephalopathy==

*Abbreviated ''CTE''.

===General===

*Due to head trauma - usu. repeated.

**Seen in ''American football'' and ''boxing''.

*May be associated with motor neuron disease.{{Cite journal | last1 = Daneshvar | first1 = DH. | last2 = Riley | first2 = DO. | last3 = Nowinski | first3 = CJ. | last4 = McKee | first4 = AC. | last5 = Stern | first5 = RA. | last6 = Cantu | first6 = RC. | title = Long-term consequences: effects on normal development profile after concussion. | journal = Phys Med Rehabil Clin N Am | volume = 22 | issue = 4 | pages = 683-700 | month = Nov | year = 2011 | doi = 10.1016/j.pmr.2011.08.009 | PMID = 22050943 }}

===Microscopic===

Features:<ref name=pmid22035690>{{Cite journal | last1 = Stern | first1 = RA. | last2 = Riley | first2 = DO. | last3 = Daneshvar | first3 = DH. | last4 = Nowinski | first4 = CJ. | last5 = Cantu | first5 = RC. | last6 = McKee | first6 = AC. | title = Long-term Consequences of Repetitive Brain Trauma: Chronic Traumatic Encephalopathy. | journal = PM R | volume = 3 | issue = 10 Suppl 2 | pages = S460-7 | month = Oct | year = 2011 | doi = 10.1016/j.pmrj.2011.08.008 | PMID = 22035690 }}</ref>

*Wall-to-wall neurofibrillary tangles.

**Common in olfactory bulb, mammillary bodies, hippocampus.

**Usually perivascular.

**Often superficial (unlike [[Alzheimer disease]]) and at the deep aspect of sulci.

===IHC===

*Increased TDP-43 staining.

Note:

*ALS associated with trauma brain injuries.<ref>{{Cite journal | last1 = Costanza | first1 = A. | last2 = Weber | first2 = K. | last3 = Gandy | first3 = S. | last4 = Bouras | first4 = C. | last5 = Hof | first5 = PR. | last6 = Giannakopoulos | first6 = P. | last7 = Canuto | first7 = A. | title = Review: Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates. | journal = Neuropathol Appl Neurobiol | volume = 37 | issue = 6 | pages = 570-84 | month = Oct | year = 2011 | doi = 10.1111/j.1365-2990.2011.01186.x | PMID = 21696410 }}</ref>

==Huntington disease==

===General===

Line 357:

Line 377:

*Mutation: unstable CAG repeat.<ref name=pmid20360611>{{cite journal |author=Kumar P, Kalonia H, Kumar A |title=Huntington's disease: pathogenesis to animal models |journal=Pharmacol Rep |volume=62 |issue=1 |pages=1–14 |year=2010 |pmid=20360611 |doi= |url=}}</ref>

===Gross===

*~~Missing~~ caudate.<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/NeuroTest/Q07-Ans.htm http://moon.ouhsc.edu/kfung/jty1/NeuroTest/Q07-Ans.htm]. Accessed on: 29 October 2010.</ref>

*Severe caudate atrophic.<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/NeuroTest/Q07-Ans.htm http://moon.ouhsc.edu/kfung/jty1/NeuroTest/Q07-Ans.htm]. Accessed on: 29 October 2010.</ref>

Image: [http://moon.ouhsc.edu/kfung/jty1/NeuroTest/Q07-Ans.htm Huntington's disease (ouhsc.edu)].

Difference between revisions of "Neurodegenerative diseases"

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@@ Line 352: / Line 352: @@
 =Other=
+==Chronic traumatic encephalopathy==
+*Abbreviated ''CTE''.
+===General===
+*Due to head trauma - usu. repeated.
+**Seen in ''American football'' and ''boxing''.
+*May be associated with motor neuron disease.{{Cite journal  | last1 = Daneshvar | first1 = DH. | last2 = Riley | first2 = DO. | last3 = Nowinski | first3 = CJ. | last4 = McKee | first4 = AC. | last5 = Stern | first5 = RA. | last6 = Cantu | first6 = RC. | title = Long-term consequences: effects on normal development profile after concussion. | journal = Phys Med Rehabil Clin N Am | volume = 22 | issue = 4 | pages = 683-700 | month = Nov | year = 2011 | doi = 10.1016/j.pmr.2011.08.009 | PMID = 22050943 }}
+===Microscopic===
+Features:<ref name=pmid22035690>{{Cite journal  | last1 = Stern | first1 = RA. | last2 = Riley | first2 = DO. | last3 = Daneshvar | first3 = DH. | last4 = Nowinski | first4 = CJ. | last5 = Cantu | first5 = RC. | last6 = McKee | first6 = AC. | title = Long-term Consequences of Repetitive Brain Trauma: Chronic Traumatic Encephalopathy. | journal = PM R | volume = 3 | issue = 10 Suppl 2 | pages = S460-7 | month = Oct | year = 2011 | doi = 10.1016/j.pmrj.2011.08.008 | PMID = 22035690 }}</ref>
+*Wall-to-wall neurofibrillary tangles.
+**Common in olfactory bulb, mammillary bodies, hippocampus.
+**Usually perivascular.
+**Often superficial (unlike [[Alzheimer disease]]) and at the deep aspect of sulci.
+===IHC===
+*Increased TDP-43 staining.
+Note:
+*ALS associated with trauma brain injuries.<ref>{{Cite journal  | last1 = Costanza | first1 = A. | last2 = Weber | first2 = K. | last3 = Gandy | first3 = S. | last4 = Bouras | first4 = C. | last5 = Hof | first5 = PR. | last6 = Giannakopoulos | first6 = P. | last7 = Canuto | first7 = A. | title = Review: Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates. | journal = Neuropathol Appl Neurobiol | volume = 37 | issue = 6 | pages = 570-84 | month = Oct | year = 2011 | doi = 10.1111/j.1365-2990.2011.01186.x | PMID = 21696410 }}</ref>
 ==Huntington disease==
 ===General===
@@ Line 357: / Line 377: @@
 *Mutation: unstable CAG repeat.<ref name=pmid20360611>{{cite journal |author=Kumar P, Kalonia H, Kumar A |title=Huntington's disease: pathogenesis to animal models |journal=Pharmacol Rep |volume=62 |issue=1 |pages=1–14 |year=2010 |pmid=20360611 |doi= |url=}}</ref>
 ===Gross===
-*Missing caudate.<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/NeuroTest/Q07-Ans.htm http://moon.ouhsc.edu/kfung/jty1/NeuroTest/Q07-Ans.htm]. Accessed on: 29 October 2010.</ref>
+*Severe caudate atrophic.<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/NeuroTest/Q07-Ans.htm http://moon.ouhsc.edu/kfung/jty1/NeuroTest/Q07-Ans.htm]. Accessed on: 29 October 2010.</ref>
 Image: [http://moon.ouhsc.edu/kfung/jty1/NeuroTest/Q07-Ans.htm Huntington's disease (ouhsc.edu)].