Difference between revisions of "Colon"
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m (→Surgery: +note about TME) |
(→Microscopic colitis: adj. format) |
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*Clinical DDx includes [[irritable bowel syndrome]] - which has no or subtle histopathologic changes. | *Clinical DDx includes [[irritable bowel syndrome]] - which has no or subtle histopathologic changes. | ||
===Microscopic colitis - types=== | ====Microscopic colitis - types==== | ||
*Lymphocytic colitis (LC). | *Lymphocytic colitis (LC). | ||
*Collagenous colitis (CC). | *Collagenous colitis (CC). | ||
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Some believe that LC and CC are different time points in the same process-- but this is unproven.<ref name=medscape180664/> | Some believe that LC and CC are different time points in the same process-- but this is unproven.<ref name=medscape180664/> | ||
===Epidemiology=== | ====Epidemiology==== | ||
*Age: a disease of adults - usually 50s. | *Age: a disease of adults - usually 50s. | ||
*Sex: | *Sex: | ||
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*No increased risk of colorectal carcinoma.<ref name=pmid19109861/> | *No increased risk of colorectal carcinoma.<ref name=pmid19109861/> | ||
===Treatment=== | ====Treatment==== | ||
*Sometimes just follow-up. | *Sometimes just follow-up. | ||
*Steroids - budesonide -- short-term treatment.<ref name=pmid19109861/> | *Steroids - budesonide -- short-term treatment.<ref name=pmid19109861/> | ||
=== | ===Microscopic=== | ||
====Lymphocytic colitis==== | ====Lymphocytic colitis==== | ||
Features: | |||
*Lots of intraepithelial lymphocytes (>=20/100 lymphocytes/surface epithelial cells<ref name=pmid19109861>{{cite journal |author=Tysk C, Bohr J, Nyhlin N, Wickbom A, Eriksson S |title=Diagnosis and management of microscopic colitis |journal=World J. Gastroenterol. |volume=14 |issue=48 |pages=7280-8 |year=2008 |month=December |pmid=19109861 |doi= |url=http://www.wjgnet.com/1007-9327/14/7280.asp}}</ref>) and | *Lots of intraepithelial lymphocytes (>=20/100 lymphocytes/surface epithelial cells<ref name=pmid19109861>{{cite journal |author=Tysk C, Bohr J, Nyhlin N, Wickbom A, Eriksson S |title=Diagnosis and management of microscopic colitis |journal=World J. Gastroenterol. |volume=14 |issue=48 |pages=7280-8 |year=2008 |month=December |pmid=19109861 |doi= |url=http://www.wjgnet.com/1007-9327/14/7280.asp}}</ref>) and | ||
*lymphocytes in the lamina propria. | *lymphocytes in the lamina propria. | ||
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====Collagenous colitis==== | ====Collagenous colitis==== | ||
Features: | |||
*Intraepithelial lymphocytes, and | *Intraepithelial lymphocytes, and | ||
*lymphocytes in the lamina propria. | *lymphocytes in the lamina propria. | ||