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Difference between revisions of "Castleman disease"
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==Microscopic== | ==Microscopic== | ||
===Hyaline-vascular variant=== | ===Hyaline-vascular variant=== | ||
Features:<ref>URL: [http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html]. Accessed on: 15 June 2010.</ref><ref name=Ref_ILNP236>{{Ref ILNP|236}}</ref><ref name=pmid28100459>{{cite journal | | Features:<ref>URL: [http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html http://www.ispub.com/journal/the_internet_journal_of_otorhinolaryngology/volume_9_number_2_11/article/a_rare_case_of_castleman_s_disease_presenting_as_cervical_neck_mass.html]. Accessed on: 15 June 2010.</ref><ref name=Ref_ILNP236>{{Ref ILNP|236}}</ref><ref name=pmid28100459>{{cite journal |authors=Yu L, Tu M, Cortes J, Xu-Monette ZY, Miranda RN, Zhang J, Orlowski RZ, Neelapu S, Boddu PC, Akosile MA, Uldrick TS, Yarchoan R, Medeiros LJ, Li Y, Fajgenbaum DC, Young KH |title=Clinical and pathological characteristics of HIV- and HHV-8-negative Castleman disease |journal=Blood |volume=129 |issue=12 |pages=1658–1668 |date=March 2017 |pmid=28100459 |pmc=5364343 |doi=10.1182/blood-2016-11-748855 |url=}}</ref> | ||
*Pale concentric (expanded) mantle zone lymphocytes - '''key feature'''. | *Pale concentric (expanded) mantle zone lymphocytes - '''key feature'''. | ||
| Line 98: | Line 98: | ||
*Sinus preserved. | *Sinus preserved. | ||
*In HHV8-negative cases, several other conditions can give a Castleman-like appearance, listed comprehensively in the consensus criteria for HHV8-negative CD: | *In HHV8-negative cases, several other conditions can give a Castleman-like appearance, listed comprehensively in the consensus criteria for HHV8-negative CD: | ||
<ref name=pmid28087540>{{cite journal | | <ref name=pmid28087540>{{cite journal |authors=Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, Simpson D, Liu AY, Menke D, Chandrakasan S, Lechowicz MJ, Wong RS, Pierson S, Paessler M, Rossi JF, Ide M, Ruth J, Croglio M, Suarez A, Krymskaya V, Chadburn A, Colleoni G, Nasta S, Jayanthan R, Nabel CS, Casper C, Dispenzieri A, Fosså A, Kelleher D, Kurzrock R, Voorhees P, Dogan A, Yoshizaki K, van Rhee F, Oksenhendler E, Jaffe ES, Elenitoba-Johnson KS, Lim MS |title=International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease |journal=Blood |volume=129 |issue=12 |pages=1646–1657 |date=March 2017 |pmid=28087540 |pmc=5364342 |doi=10.1182/blood-2016-10-746933 |url=}}</ref> | ||
**Autoimmune diseases | **Autoimmune diseases | ||
**Infections | **Infections | ||