Difference between revisions of "Neurodegenerative diseases"
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==Neuronal Intermediate Filament Inclusion Disease== | ==Neuronal Intermediate Filament Inclusion Disease== | ||
* AKA: NIFID. | * AKA: NIFID. | ||
* Hyaline conglomerates (brightly eosinophilic branching fibrillar structures embedded in a round, well-delineated, glassy vacuole). | * Sporadic early‐onset frontotemporal dementia, motor neuron disease, extrapyramidal motor symptoms. | ||
* FUS+ve (heterogenous). | * Hyaline conglomerates (brightly eosinophilic branching fibrillar structures embedded in a round, well-delineated, glassy vacuole). | ||
* Deposits in cerebral cortex, hippocampus, basal ganglia, thalamus, cerebellar dentate, numerous brainstem nuclei and lower motor neurons. | |||
* FUS+ve/EWS+ve/TAF15+ve (heterogenous). | |||
** FET+ve filamentous nuclear inclusions in the hippocampus. | |||
* Ubiquitin +/-ve. | * Ubiquitin +/-ve. | ||
* NF +ve (some subunits). | * NF +ve (some subunits). | ||