Difference between revisions of "Endometriosis"
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==Diagnosis== | ==Diagnosis== | ||
Criteria - need at least 2 / 3 for the diagnosis:<ref name=Ref_DCHH239>{{Ref DCHH|239}}</ref> | |||
#Endometrial glands - endometrial glands are classically: circular, with nuclei that are hyperchromatic & cigar-shaped. | #Endometrial glands - endometrial glands are classically: circular, with nuclei that are hyperchromatic & cigar-shaped. | ||
#Endometrial stroma - endometrial stroma is classically: cellular and hyperchromatic (may resemble a lymphocytic infiltration on low power). | #Endometrial stroma - endometrial stroma is classically: cellular and hyperchromatic (may resemble a lymphocytic infiltration on low power). | ||
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Notes: | Notes: | ||
*The epithelial component (1) may appear cuboidal in cysts ''or'' be sloughed-off, i.e. absent. | *The epithelial component (1) may appear cuboidal in cysts ''or'' be sloughed-off, i.e. absent. | ||
*The microscopic correlation of '' | *The microscopic correlation of ''chocolate cyst'' is: light brown acellular material; this can be considered as a substitute for (3) - ''hemosiderin-laden macrophages''. | ||
*Epithelial component may have tubal metaplasia.<ref name=pmid17592255>{{cite journal |author=Clement PB |title=The pathology of endometriosis: a survey of the many faces of a common disease emphasizing diagnostic pitfalls and unusual and newly appreciated aspects |journal=Adv Anat Pathol |volume=14 |issue=4 |pages=241–60 |year=2007 |month=July |pmid=17592255 |doi=10.1097/PAP.0b013e3180ca7d7b |url=}}</ref> | *Epithelial component may have tubal metaplasia.<ref name=pmid17592255>{{cite journal |author=Clement PB |title=The pathology of endometriosis: a survey of the many faces of a common disease emphasizing diagnostic pitfalls and unusual and newly appreciated aspects |journal=Adv Anat Pathol |volume=14 |issue=4 |pages=241–60 |year=2007 |month=July |pmid=17592255 |doi=10.1097/PAP.0b013e3180ca7d7b |url=}}</ref> | ||
*Endometriosis may mimic cancer... | *Endometriosis may mimic cancer - see image below. | ||
*If it is just endometrial type glands... it is probably [[endosalpingiosis]]. | |||
===Images=== | ===Images=== | ||
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==Associations== | ==Associations== | ||
Endometriosis is associated with: | Endometriosis is associated with: | ||
* | *Endometrioid adenocarcinoma of the [[ovarian tumours|ovary]]<ref>{{cite journal |author=Nagle CM, Olsen CM, Webb PM, Jordan SJ, Whiteman DC, Green AC |title=Endometrioid and clear cell ovarian cancers: a comparative analysis of risk factors |journal=Eur. J. Cancer |volume=44 |issue=16 |pages=2477-84 |year=2008 |month=November |pmid=18707869 |doi=10.1016/j.ejca.2008.07.009 |url=}}</ref> | ||
*Clear cell carcinoma of the ovary.<ref name=pmid18834345>{{cite journal |author=Kawaguchi R, Tsuji Y, Haruta S, ''et al.'' |title=Clinicopathologic features of ovarian cancer in patients with ovarian endometrioma |journal=J. Obstet. Gynaecol. Res. |volume=34 |issue=5 |pages=872–7 |year=2008 |month=October |pmid=18834345 |doi=10.1111/j.1447-0756.2008.00849.x |url=}}</ref> | *Clear cell carcinoma of the ovary.<ref name=pmid18834345>{{cite journal |author=Kawaguchi R, Tsuji Y, Haruta S, ''et al.'' |title=Clinicopathologic features of ovarian cancer in patients with ovarian endometrioma |journal=J. Obstet. Gynaecol. Res. |volume=34 |issue=5 |pages=872–7 |year=2008 |month=October |pmid=18834345 |doi=10.1111/j.1447-0756.2008.00849.x |url=}}</ref> | ||
*Increased endocrine tumours, [[non-Hodgkin's lymphoma]], brain tumours and decreased [[cervical cancer]].<ref>[http://www.medicalnewstoday.com/articles/3890.php http://www.medicalnewstoday.com/articles/3890.php]</ref> | *Increased endocrine tumours, [[non-Hodgkin's lymphoma]], brain tumours and decreased [[cervical cancer]].<ref>[http://www.medicalnewstoday.com/articles/3890.php http://www.medicalnewstoday.com/articles/3890.php]</ref> | ||
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==Immunohistochemical stains== | ==Immunohistochemical stains== | ||
* | *CD10 [[stains]] the stromal cells<ref name=Ref_DCHH236>{{Ref DCHH|236}}</ref> - used to look for endometriosis. | ||
==See also== | ==See also== | ||