Difference between revisions of "Adrenal gland"
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==Neuroblastoma== | ==Neuroblastoma== | ||
===General=== | ===General=== | ||
* | Laboratory: | ||
*Increased urine homovanillic acid. | |||
Epidemiology: | Epidemiology: | ||
*Usually paediatric population. | *Usually paediatric population. | ||
Classification: | |||
*In a grouping known as ''neuoblastic tumours'' which includes:<ref name=pmid10421272>{{cite journal |author=Shimada H, Ambros IM, Dehner LP, Hata J, Joshi VV, Roald B |title=Terminology and morphologic criteria of neuroblastic tumors: recommendations by the International Neuroblastoma Pathology Committee |journal=Cancer |volume=86 |issue=2 |pages=349–63 |year=1999 |month=July |pmid=10421272 |doi= |url=}}</ref> | |||
**Ganglioneuroma (benign). | |||
**Ganglioblastoma (intermediate). | |||
**Neuroblastoma (aggressive). | |||
===Microscopic=== | ===Microscopic=== | ||
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*Homer-Wright rosettes. | *Homer-Wright rosettes. | ||
**Rosette with a small (~100 micrometers - diameter) meshwork of fibers (neuropil) at the centre.<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | **Rosette with a small (~100 micrometers - diameter) meshwork of fibers (neuropil) at the centre.<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | ||
*Neuropil-like stroma (see below). | |||
Notes: | Notes: | ||
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DDx: | DDx: | ||
*[[Small round cell tumours]]. | *[[Small round cell tumours]]. | ||
Images: | Images: | ||
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*[http://commons.wikimedia.org/wiki/File:Neuroblastoma_rosettes.jpg Neuroblastoma (WC)]. | *[http://commons.wikimedia.org/wiki/File:Neuroblastoma_rosettes.jpg Neuroblastoma (WC)]. | ||
*[http://farm3.static.flickr.com/2259/2274260465_afbea05f9b.jpg Neuroblastoma (flickr.com)]. | *[http://farm3.static.flickr.com/2259/2274260465_afbea05f9b.jpg Neuroblastoma (flickr.com)]. | ||
====Schwannian vs. neuropil==== | |||
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto" | |||
| Feature | |||
| Schwannian | |||
| Neuropil | |||
|- | |||
| Cellularity | |||
| high ~ spacing of cells < 30 µm | |||
| low ~ spacing of cells > 100 µm | |||
|- | |||
| Fibrillary | |||
| yes, long fine strands | |||
| no | |||
|- | |||
| Associations | |||
| ganglion cells | |||
| neuroblasts | |||
|- | |||
| Cytoplasmic vacuolation | |||
| yes | |||
| ? | |||
|- | |||
|} | |||
=See also= | =See also= | ||