Difference between revisions of "Wilson's disease"

Line 22:

*[[Steatosis of the liver|Steatosis]].

*Portal fibrosis.

{|

[[File:1 Wilson 1 680x512px.tif|Inflamed & relatively unaffected segments (40X).]]

A. [[File:1 Wilson 1 680x512px.tif|Inflamed & relatively unaffected segments (40X).]]

[[File:2 Wilson 1 680x512px.tif|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (200X).]]

B. [[File:2 Wilson 1 680x512px.tif|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] (200X).]]

C. [[File:3 Wilson 1 680x512px.tif|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]

[[File:3 Wilson 1 680x512px.tif|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]

D. [[File:4 Wilson 1 680x512px.tif|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]

[[File:4 Wilson 1 680x512px.tif|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]

Wilson’s disease, pre-cirrhotic. A. Inflamed & relatively unaffected segments. B. Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes]. C. Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli. D. Trichrome shows periportal & sinusoidal fibrosis.

|}

Wilson’s disease, pre-cirrhotic. Inflamed & relatively unaffected segments ~~(UL 40X)~~. Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes] ~~(UR 200X)~~. Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli ~~(LL 400X)~~. Trichrome shows periportal & sinusoidal fibrosis (~~LR 100X~~).

[[File:4 38555059990939 sl 1.png|Wilson’s disease with cirrhosis]]

[[File:4 38555059990939 sl 2.png|Wilson’s disease with cirrhosis]]

[[File:4 38555059990939 sl 3.png|Wilson’s disease with cirrhosis]]

[[File:4 38555059990939 sl 4.png|Wilson’s disease with cirrhosis]]

[[File:4 38555059990939 sl 5.png|Wilson’s disease with cirrhosis]]

Wilson’s disease with cirrhosis in a 22 year old woman. A. Nodules show steatosis without definite triads. B. Trichrome shows minute fibrous bound nodules in this case. C. Reticulin shows extensive regeneration (2-3 nuclei thick cords with lack of direction) with nodule formation. D. Bridge with extensive proliferated bile ductules and acute and chronic inflammatory cells. E. Ballooning degeneration with Mallory bodies.

==Stains==

Difference between revisions of "Wilson's disease"

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@@ Line 22: / Line 22: @@
 *[[Steatosis of the liver|Steatosis]].
 *Portal fibrosis.
-{|
-[[File:1 Wilson 1 680x512px.tif|Inflamed & relatively unaffected segments  (40X).]]
+A. [[File:1 Wilson 1 680x512px.tif|Inflamed & relatively unaffected segments  (40X).]]<br>
-[[File:2 Wilson 1 680x512px.tif|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes]  (200X).]]
+B. [[File:2 Wilson 1 680x512px.tif|Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes]  (200X).]]<br>
-<br>
+C. [[File:3 Wilson 1 680x512px.tif|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]<br>
-[[File:3 Wilson 1 680x512px.tif|Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (400X).]]
+D. [[File:4 Wilson 1 680x512px.tif|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]<br>
-[[File:4 Wilson 1 680x512px.tif|Trichrome shows periportal & sinusoidal fibrosis. No bridging was seen. (100X).]]
+Wilson’s disease, pre-cirrhotic. A. Inflamed & relatively unaffected segments. B. Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes]. C. Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli. D. Trichrome shows periportal & sinusoidal fibrosis.
-|}
-Wilson’s disease, pre-cirrhotic. Inflamed & relatively unaffected segments  (UL 40X). Bile ductular proliferation with interface hepatitis [inflammation of periportal hepatocytes]  (UR 200X). Enlarged hepatocytes, some with feathery degeneration, others with steatosis. Nuclei show nucleoli (LL 400X). Trichrome shows periportal & sinusoidal fibrosis (LR 100X).
+[[File:4 38555059990939 sl 1.png|Wilson’s disease with cirrhosis]]
+[[File:4 38555059990939 sl 2.png|Wilson’s disease with cirrhosis]]
+[[File:4 38555059990939 sl 3.png|Wilson’s disease with cirrhosis]]
+[[File:4 38555059990939 sl 4.png|Wilson’s disease with cirrhosis]]
+[[File:4 38555059990939 sl 5.png|Wilson’s disease with cirrhosis]] <br>
+Wilson’s disease with cirrhosis in a 22 year old woman. A. Nodules show steatosis without definite triads.  B. Trichrome shows minute fibrous bound nodules in this case. C. Reticulin shows extensive regeneration (2-3 nuclei thick cords with lack of direction) with nodule formation. D. Bridge with extensive proliferated bile ductules and acute and chronic inflammatory cells. E. Ballooning degeneration with Mallory bodies.
 ==Stains==