Difference between revisions of "Desquamative interstitial pneumonia"
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| Staging = | | Staging = | ||
| Site = [[lung]] - see ''[[diffuse lung diseases]]'' | | Site = [[lung]] - see ''[[diffuse lung diseases]]'' | ||
| Assdx = [[smoking]] | | Assdx = +/-[[smoking]] | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = | | Clinicalhx = | ||
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| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = | ||
| Tx = stop smoking | | Tx = stop smoking/remove insult | ||
}} | }} | ||
'''Desquamative interstitial pneumonia''', abbreviated '''DIP''', is a [[diffuse lung diseases|diffuse lung disease]] that is strongly associated with [[smoking]]. | '''Desquamative interstitial pneumonia''', abbreviated '''DIP''', is a [[diffuse lung diseases|diffuse lung disease]] that is strongly associated with [[smoking]]. | ||
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**Thought to be advanced ''[[RBILD]]''. | **Thought to be advanced ''[[RBILD]]''. | ||
*May be seen in non-smokers (up to ~40% of cases) due to occupational exposures, drugs, viral illnesses and autoimmune diseases.<ref name=pmid23728865>{{Cite journal | last1 = Godbert | first1 = B. | last2 = Wissler | first2 = MP. | last3 = Vignaud | first3 = JM. | title = Desquamative interstitial pneumonia: an analytic review with an emphasis on aetiology. | journal = Eur Respir Rev | volume = 22 | issue = 128 | pages = 117-23 | month = Jun | year = 2013 | doi = 10.1183/09059180.00005812 | PMID = 23728865 }}</ref> | *May be seen in non-smokers (up to ~40% of cases) due to occupational exposures, drugs, viral illnesses and autoimmune diseases.<ref name=pmid23728865>{{Cite journal | last1 = Godbert | first1 = B. | last2 = Wissler | first2 = MP. | last3 = Vignaud | first3 = JM. | title = Desquamative interstitial pneumonia: an analytic review with an emphasis on aetiology. | journal = Eur Respir Rev | volume = 22 | issue = 128 | pages = 117-23 | month = Jun | year = 2013 | doi = 10.1183/09059180.00005812 | PMID = 23728865 }}</ref> | ||
Diagnosis: | |||
*Requires - surgical biopsy.<ref name=pmid23728865/> | |||
Treatment: | Treatment: | ||
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==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid20854463>{{Cite journal | last1 = Tazelaar | first1 = HD. | last2 = Wright | first2 = JL. | last3 = Churg | first3 = A. | title = Desquamative interstitial pneumonia. | journal = Histopathology | volume = 58 | issue = 4 | pages = 509-16 | month = Mar | year = 2011 | doi = 10.1111/j.1365-2559.2010.03649.x | PMID = 20854463 }}</ref> | ||
*Abundant brown pigmented airspace macrophages - ''smoker's macrophages'' - '''key feature'''. | *Abundant brown pigmented airspace macrophages - ''smoker's macrophages'' - '''key feature'''. | ||
* | *Interstitial inflammation ''or'' interstitial fibrosis with preserved architecture preserved - so called "linear fibrosis". | ||
Notes: | Notes: | ||