Difference between revisions of "Neuropathology"
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(→Pathology: more on CPM) |
(→Hypoxic-ischemic encephalopathy: +hippocampal, +laminar necrosis) |
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***Cavitation: bubbles/clear spaces where there should be none. | ***Cavitation: bubbles/clear spaces where there should be none. | ||
**CA2 neurons preserved/resistant. | **CA2 neurons preserved/resistant. | ||
*Purkinje cell loss in the cerebellum and [[Bergmann gliosis]]. | *Purkinje cell loss in the cerebellum and [[Bergmann gliosis]]. | ||
*"Anoxic neurons".<ref>URL: [http://www.neuropathologyweb.org/chapter2/chapter2aHIE.html http://www.neuropathologyweb.org/chapter2/chapter2aHIE.html]. Accessed on: 12 July 2010.</ref> | *"Anoxic neurons".<ref>URL: [http://www.neuropathologyweb.org/chapter2/chapter2aHIE.html http://www.neuropathologyweb.org/chapter2/chapter2aHIE.html]. Accessed on: 12 July 2010.</ref> | ||
**Shrunken neurons with intensely eosinophilic cytoplasm and pyknotic (shrunken) nuclei. | **Shrunken neurons with intensely eosinophilic cytoplasm and pyknotic (shrunken) nuclei. | ||
* | *Pseudolaminar necrosis - (uncontrolled) cell death in the cerebral cortex in a band-like pattern,<ref>Hypoxic and Ischemic Encephalopathy. neuropathology.neoucom.edu. Accessed on: 29 December 2010.</ref> with a relative preservation of cells immediately adjacent to the meninges. | ||
***[http://www.neuropathologyweb.org/chapter2/images2/2-1HIE.jpg Anoxic neurons (neuropathologyweb.org)]. | |||
Images: | |||
*Anoxic neurons: | |||
**[http://www.neuropathologyweb.org/chapter2/images2/2-1HIE.jpg Anoxic neurons (neuropathologyweb.org)]. | |||
**[http://commons.wikimedia.org/wiki/File:Alzheimer_type_II_astrocyte_high_mag_cropped.jpg Anoxic neurons (WC)]. | |||
**[http://moon.ouhsc.edu/kfung/iacp-olp/APAQ-Images/N1-MS-01-16.gif Anoxic neurons (ouhsc.edu)].<ref>URL: [http://moon.ouhsc.edu/kfung/iacp-olp/apaq-text/N1-MS-01-16-Ans.htm http://moon.ouhsc.edu/kfung/iacp-olp/apaq-text/N1-MS-01-16-Ans.htm] and [http://moon.ouhsc.edu/kfung/iacp-olp/apaq-text/n1-ms-01.htm http://moon.ouhsc.edu/kfung/iacp-olp/apaq-text/n1-ms-01.htm]. Accessed on: 31 October 2010.</ref> | |||
*Hippocampal ischemic changes: | |||
**[http://www.neuropathologyweb.org/chapter2/images2/2-hippoHIE.jpg Hippocampus in HIE (neuropathologyweb.org).<ref>URL: [http://www.neuropathologyweb.org/chapter2/chapter2aHIE.html http://www.neuropathologyweb.org/chapter2/chapter2aHIE.html]. Accessed on: 14 January 2011.</ref> | |||
*Pseudolaminar necrosis: | |||
**[http://commons.wikimedia.org/wiki/File:Cortical_pseudolaminar_necrosis_-_lfb_-_very_low_mag.jpg Pseudolaminar necrosis - very low mag. (WC)]. | |||
**[http://commons.wikimedia.org/wiki/File:Cortical_pseudolaminar_necrosis_-_lfb_-_intermed_mag.jpg Pseudolaminar necrosis - intermed. mag. (WC)]. | |||
Notes: | |||
*Neurons of ''subiculum'' in adults - usu. normal (as they are resistant to ischemic changes). | |||
==Multiple sclerosis== | ==Multiple sclerosis== |