Difference between revisions of "Salivary glands"
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==Salivary duct carcinoma== | ==Salivary duct carcinoma== | ||
===General=== | |||
*Malignant counterpart of ''salivary duct adenoma''. | |||
*Male:female ~= 4:1. | |||
*Typically >50 years old. | |||
*Mostly in the parotid. | |||
===Microscopic=== | |||
Features: | |||
*Architecture: sheets, nests, cords, cribriform, micropapillary. | |||
*Neoplastic cells line-up around cystic spaces "Roman bridges". | |||
*Nuclear atypia (variation in size, shape, staining). | |||
*Apocrine snouts - pseudopod-like/lollipop-like undulations of the cell membrane. | |||
*Decapitation secretions - apocrine snouts (membrane bound blobs of cytoplasm) that have separated from its mother cell. | |||
Image: | |||
*[http://www.webpathology.com/image.asp?case=122&n=2 Salivary duct carcinoma (webpathology.com)]. | |||
* | Notes: | ||
*Similar to ductal breast carcinoma. | |||
====Subtypes==== | |||
*Conventional. | |||
*Mucinous - worse prognosis; opposite of what would one expect from the outcomes in [[breast cancer]]. | |||
*Micropapillary - assoc. with a poor prognosis. | |||
*Sarcomatoid/spindle cell. | |||
===IHC=== | |||
*LMWK, EMA, CK7, CK19 +ve. | |||
*p63 -ve. | |||
*Androgen receptor +ve. | |||
*BRST2 (GCDFP-15) +ve. | |||
*HER2 +ve ~21%; use of trastuzumab (Herceptin) not systematically studied. | |||
Curiosity: | |||
*PSA +/-. | |||
*PSAP +/-. | |||
==Polymorphous low-grade adenocarcinoma== | ==Polymorphous low-grade adenocarcinoma== | ||