Difference between revisions of "Mixed germ cell tumour"
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(→IHC) |
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| Symptoms = | | Symptoms = | ||
| Prevalence = most common germ cell tumour | | Prevalence = most common germ cell tumour | ||
| Bloodwork = +/-AFP elevated, +/-beta-hCG elevated, +/-LDH elevated | | Bloodwork = +/-[[AFP]] elevated, +/-beta-hCG elevated, +/-LDH elevated | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Line 75: | Line 75: | ||
Looking for elements | Looking for elements | ||
*Beta-hCG +ve - if syncytiotrophoblasts are present. | *Beta-hCG +ve - if syncytiotrophoblasts are present. | ||
*AFP +ve (or Glypican 3 +ve) - a yolk sac tumour component is present. | *[[AFP]] +ve (or Glypican 3 +ve) - a yolk sac tumour component is present. | ||
*GFAP +ve - if neuroepithelium is present. | *GFAP +ve - if neuroepithelium is present. | ||
| Line 84: | Line 84: | ||
*Pankeratin +ve -- embryonal carcinoma. | *Pankeratin +ve -- embryonal carcinoma. | ||
*CEA-M. | *CEA-M. | ||
*EMA +ve -- metastatic carcinoma.<ref>{{Cite journal | last1 = Shek | first1 = TW. | last2 = Yuen | first2 = ST. | last3 = Luk | first3 = IS. | last4 = Wong | first4 = MP. | title = Germ cell tumour as a diagnostic pitfall of metastatic carcinoma. | journal = J Clin Pathol | volume = 49 | issue = 3 | pages = 223-5 | month = Mar | year = 1996 | doi = | PMID = 8675733 }}</ref> | *[[EMA]] +ve -- metastatic carcinoma.<ref>{{Cite journal | last1 = Shek | first1 = TW. | last2 = Yuen | first2 = ST. | last3 = Luk | first3 = IS. | last4 = Wong | first4 = MP. | title = Germ cell tumour as a diagnostic pitfall of metastatic carcinoma. | journal = J Clin Pathol | volume = 49 | issue = 3 | pages = 223-5 | month = Mar | year = 1996 | doi = | PMID = 8675733 }}</ref> | ||
*Vimentin. | *Vimentin. | ||
*Glypican 3 +ve -- [[yolk sac tumour]]. | *Glypican 3 +ve -- [[yolk sac tumour]]. | ||