Difference between revisions of "Metaphyseal fibrous defect"
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*Rarely seen as a pathologic specimen (should not be biopsied). | *Rarely seen as a pathologic specimen (should not be biopsied). | ||
*May be seen in the context of ''Jaffe-Campanacci syndrome''.<ref>URL: [http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome]. Accessed on: October 14, 2014.</ref> | *May be seen in the context of ''Jaffe-Campanacci syndrome''.<ref>URL: [http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome http://www.bonetumor.org/plasma-cell-tumors/jaffe-campanacci-syndrome]. Accessed on: October 14, 2014.</ref> | ||
*Radiographic diagnosis. | |||
Clinical history: | Clinical history: | ||
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*Pathologic fracture. | *Pathologic fracture. | ||
Treatment: | |||
* | *None (spontaneously resolve by ossification). | ||
**Diagnosis is part of the ''skeletal do not touch list''.<ref>URL: [http://radiopaedia.org/articles/skeletal-do-not-touch-lesions-1 http://radiopaedia.org/articles/skeletal-do-not-touch-lesions-1]. Accessed on: October 14, 2014.</ref> | |||
* | |||
== | Notes: | ||
*Metaphysis of distal femur or proximal tibia (80%). | *May resolve into a ''bone island''. | ||
Clinical DDx: | |||
*''FOG MACHINES'' acronym for radiographically lytic bone lesions.<ref>URL: [http://radiopaedia.org/articles/lytic-bone-lesion-mnemonic http://radiopaedia.org/articles/lytic-bone-lesion-mnemonic]. Accessed on: October 14, 2014.</ref> | |||
==Gross== | |||
*Firm, granular, brown to yellow to red. | |||
Site: | |||
*[[Metaphysis]] of distal femur or proximal tibia (80%). | |||
*Cortical. | *Cortical. | ||
* | *Metaphysis. | ||
*Long bones. | *Long bones. | ||
*Eccentric location. | *Eccentric location. | ||
==Microscopic== | ==Microscopic== | ||
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DDx (microscopic): | DDx (microscopic): | ||
*[[Giant cell tumour of bone]] - [[epiphysis|epiphyseal]] location, occurs in adults. | *[[Giant cell tumour of bone]] - [[epiphysis|epiphyseal]] location, occurs in adults. | ||
*Other [[giant cell lesions]] of bone. | |||
*[[Spindle cell lesion]]s of bone. | |||
* | |||
==Images== | ==Images== | ||
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==IHC== | ==IHC== | ||
*Not relevant | *Not relevant. | ||
==Molecular== | ==Molecular== | ||
*Not relevant | *Not relevant. | ||
==Radiographic findings== | ==Radiographic findings== | ||
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==Sign out== | ==Sign out== | ||
<pre> | <pre> | ||
BONE, CURETTAGE: METAPHYSEAL FIBROUS DEFECT / NONOSSIFYING FIBROMA. | BONE, CURETTAGE: | ||
- METAPHYSEAL FIBROUS DEFECT / NONOSSIFYING FIBROMA. | |||
</pre> | </pre> | ||
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==External links== | ==External links== | ||
*http://njms2.umdnj.edu/tutorweb/case8.htm | *[http://njms2.umdnj.edu/tutorweb/case8.htm A case of MFD (umdnj.edu)]. | ||
*[http://radiopaedia.org/articles/fibrous-cortical-defect Fibrous cortical defect (radiopaedia.org)]. | |||
*http://radiopaedia.org/articles/fibrous-cortical-defect | *[http://radiopaedia.org/articles/non-ossifying-fibroma-1 Non-ossifying fibroma (radiopaedia.org)]/ | ||
*http://radiopaedia.org/articles/non-ossifying-fibroma-1 | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Bone]] | [[Category:Bone]] | ||