Difference between revisions of "Desmoid-type fibromatosis"

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*Beta-catenin +ve (nuclear<ref name=pmid23020601/>) - '''important'''.

**100% sensitive... may not be completely specific (?).<ref name=pmid17721184>{{Cite journal | last1 = Amary | first1 = MF. | last2 = Pauwels | first2 = P. | last3 = Meulemans | first3 = E. | last4 = Roemen | first4 = GM. | last5 = Islam | first5 = L. | last6 = Idowu | first6 = B. | last7 = Bousdras | first7 = K. | last8 = Diss | first8 = TC. | last9 = O'Donnell | first9 = P. | title = Detection of beta-catenin mutations in paraffin-embedded sporadic desmoid-type fibromatosis by mutation-specific restriction enzyme digestion (MSRED): an ancillary diagnostic tool. | journal = Am J Surg Pathol | volume = 31 | issue = 9 | pages = 1299-309 | month = Sep | year = 2007 | doi = 10.1097/PAS.0b013e31802f581a | PMID = 17721184 }}</ref>

**Staining may be difficult to interpret as the nucleus may be small, the cytoplasm scant and the precipitate grainy and vague. Ensure that the staining seen is nuclear (or nuclear and cytoplasmic). Cytoplasmic staining alone can occur and is not a true positive.

*SMA +ve ~50% of lesions.

Difference between revisions of "Desmoid-type fibromatosis"

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@@ Line 82: / Line 82: @@
 *Beta-catenin +ve (nuclear<ref name=pmid23020601/>) - '''important'''.
 **100% sensitive... may not be completely specific (?).<ref name=pmid17721184>{{Cite journal  | last1 = Amary | first1 = MF. | last2 = Pauwels | first2 = P. | last3 = Meulemans | first3 = E. | last4 = Roemen | first4 = GM. | last5 = Islam | first5 = L. | last6 = Idowu | first6 = B. | last7 = Bousdras | first7 = K. | last8 = Diss | first8 = TC. | last9 = O'Donnell | first9 = P. | title = Detection of beta-catenin mutations in paraffin-embedded sporadic desmoid-type fibromatosis by mutation-specific restriction enzyme digestion (MSRED): an ancillary diagnostic tool. | journal = Am J Surg Pathol | volume = 31 | issue = 9 | pages = 1299-309 | month = Sep | year = 2007 | doi = 10.1097/PAS.0b013e31802f581a | PMID = 17721184 }}</ref>
+**Staining may be difficult to interpret as the nucleus may be small, the cytoplasm scant and the precipitate grainy and vague.  Ensure that the staining seen is nuclear (or nuclear and cytoplasmic).  Cytoplasmic staining alone can occur and is not a true positive.
 *SMA +ve ~50% of lesions.