Difference between revisions of "Neurodegenerative diseases"
Jump to navigation
Jump to search
(fix ref) |
(from main article neuropathology) |
||
| Line 155: | Line 155: | ||
Image: [http://moon.ouhsc.edu/kfung/jty1/NeuroTest/Q07-Ans.htm Huntington's disease (ouhsc.edu)]. | Image: [http://moon.ouhsc.edu/kfung/jty1/NeuroTest/Q07-Ans.htm Huntington's disease (ouhsc.edu)]. | ||
==Binswanger's disease== | |||
===General=== | |||
*Multi-infarct dementia affecting subcortical white matter. | |||
*Waste-basket diagnosis; diagnosed if CADASIL and amyloidosis have been excluded. | |||
*Diagnosis has been controversial -- most with this entity (in the past) were diagnosed with ''Alzheimer's disease''. | |||
===Microscopic=== | |||
Features: | |||
*Subcortical lesions that replace the myelin consisting of macrophages. | |||
==Prion diseases== | |||
Etiology:<ref name=pmid16609731>{{cite journal |author=Watts JC, Balachandran A, Westaway D |title=The expanding universe of prion diseases |journal=PLoS Pathog. |volume=2 |issue=3 |pages=e26 |year=2006 |month=March |pmid=16609731 |pmc=1434791 |doi=10.1371/journal.ppat.0020026 |url=}}</ref> | |||
*Misfolded cell-surface protein called PrP(C). | |||
Includes:<ref name=pmid16609731>{{cite journal |author=Watts JC, Balachandran A, Westaway D |title=The expanding universe of prion diseases |journal=PLoS Pathog. |volume=2 |issue=3 |pages=e26 |year=2006 |month=March |pmid=16609731 |pmc=1434791 |doi=10.1371/journal.ppat.0020026 |url=}}</ref> | |||
*Creutzfeldt-Jakob disease (CJD). | |||
*Sporadic fatal insomnia (sFI). | |||
==Creutzfeldt-Jakob disease== | |||
===General=== | |||
*Commonly abbreviated as ''CJD''. | |||
*Rare. | |||
*Incurable disease. | |||
*Usually diagnosed clinically. | |||
**Characteristic findings: | |||
***Very rapid decline (3-4 months). | |||
***Characteristic (cortex findings on) neuroradiology. | |||
====Variant Creutzfeldt-Jakob disease (vCJD)==== | |||
*Associated with bovine spongiform encephalopathy. | |||
*Should sample: spleen, lymph nodes, tonsils.<ref name=Ref_HospAuto83>{{Ref HospAuto|83}}</ref> | |||
===Microscopic=== | |||
Features: | |||
*Spongy appearance (cytoplasmic vacuolization<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/N0I002-PQ01-M.htm http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/N0I002-PQ01-M.htm]. Accessed on: 19 October 2010.</ref>). | |||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:SpongiformChangeCJD.jpg CJD (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:VCJD_Tonsil.jpg vCJD - IHC (WC)]. | |||
==See also== | ==See also== | ||