Difference between revisions of "Leiomyosarcoma"
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| Caption = Leiomyosarcoma. [[H&E stain]]. | | Caption = Leiomyosarcoma. [[H&E stain]]. | ||
| Micro = | | Micro = fasciclar arrangement (characteristic of smooth muscle), features of malignancy (usually need 2 of 3): † (1) nuclear atypia, (2) tumour cell necrosis, (3) mitoses - variable & definitions suffer from [[HPFitis]] | ||
| Subtypes = | | Subtypes = major: spindled leiomyosarcoma (leiomyosarcoma NOS), epithelioid leiomyosarcoma, myxoid leiomyosarcoma; minor: leiomyosarcoma with prominent intravascular growth, leiomyosarcoma with osteoclast-type cells, leiomyosarcoma with clear cells, leiomyosarcoma with xanthoma-type cells | ||
| LMDDx = | | LMDDx = [[pleomorphic undifferentiated sarcoma]], [[atypical fibroxanthoma]] (skin only), [[EBV-associated smooth muscle tumour]], [[carcinosarcoma]], [[smooth muscle tumour of uncertain malignant potential]] (STUMP), [[endometrial stromal sarcoma]], [[atypical leiomyoma]] (symplastic leiomyoma) | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = | ||
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| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = | | Gross = "fleshy" appearance, necrosis, large size | ||
| Grossing = | | Grossing = | ||
| Site = [[uterus]], [[skin]] | | Site = [[uterus]], [[skin]], others | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||