Difference between revisions of "Stomach"
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| +ve<ref>{{Cite journal | last1 = Rubio | first1 = CA. | title = Gastric duodenal metaplasia in duodenal adenomas. | journal = J Clin Pathol | volume = 60 | issue = 6 | pages = 661-3 | month = Jun | year = 2007 | doi = 10.1136/jcp.2006.039388 | PMID = 16837629 | PMC = 1955048 | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1955048/ }}</ref> | | +ve<ref>{{Cite journal | last1 = Rubio | first1 = CA. | title = Gastric duodenal metaplasia in duodenal adenomas. | journal = J Clin Pathol | volume = 60 | issue = 6 | pages = 661-3 | month = Jun | year = 2007 | doi = 10.1136/jcp.2006.039388 | PMID = 16837629 | PMC = 1955048 | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1955048/ }}</ref> | ||
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|Villin stain<ref name=pmid2459839>{{cite journal |author=Osborn M, Mazzoleni G, Santini D, Marrano D, Martinelli G, Weber K |title=Villin, intestinal brush border hydrolases and keratin polypeptides in intestinal metaplasia and gastric cancer; an immunohistologic study emphasizing the different degrees of intestinal and gastric differentiation in signet ring cell carcinomas |journal=Virchows Arch A Pathol Anat Histopathol |volume=413 |issue=4 |pages=303–12 |year=1988 |pmid=2459839 |doi= |url=}}</ref> | |Villin stain<ref name=pmid2459839>{{cite journal |author=Osborn M, Mazzoleni G, Santini D, Marrano D, Martinelli G, Weber K |title=Villin, intestinal brush border hydrolases and keratin polypeptides in intestinal metaplasia and gastric cancer; an immunohistologic study emphasizing the different degrees of intestinal and gastric differentiation in signet ring cell carcinomas |journal=Virchows Arch A Pathol Anat Histopathol |volume=413 |issue=4 |pages=303–12 |year=1988 |pmid=2459839 |doi= |url=}}</ref><ref>{{Cite journal | last1 = Braunstein | first1 = EM. | last2 = Qiao | first2 = XT. | last3 = Madison | first3 = B. | last4 = Pinson | first4 = K. | last5 = Dunbar | first5 = L. | last6 = Gumucio | first6 = DL. | title = Villin: A marker for development of the epithelial pyloric border. | journal = Dev Dyn | volume = 224 | issue = 1 | pages = 90-102 | month = May | year = 2002 | doi = 10.1002/dvdy.10091 | PMID = 11984877 }}</ref> | ||
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*Intraepithelial lymphocytes in the gastric mucosa have a clear halo around 'em.<ref>Sternberg H4P 2nd Ed., P.484</ref> | *Intraepithelial lymphocytes in the gastric mucosa have a clear halo around 'em.<ref>Sternberg H4P 2nd Ed., P.484</ref> | ||
*Memory device: '''F'''olveolar cells have '''f'''riends, i.e. they are close to other foveolar cells. | *Memory device: '''F'''olveolar cells have '''f'''riends, i.e. they are close to other foveolar cells. | ||
===Gastric antrum versus gastric body=== | ===Gastric antrum versus gastric body=== | ||
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**Can be ''very'' easy to miss in some biopsies. | **Can be ''very'' easy to miss in some biopsies. | ||
*Inflammation + small bacteria = suspect H. pylori gastritis. | *Inflammation + small bacteria = suspect H. pylori gastritis. | ||
=Some patterns= | |||
==Gastric atrophy== | |||
===General=== | |||
*Has a wide differential diagnosis. | |||
===Microscopic=== | |||
Can take three general forms: | |||
#Intestinal metaplasia - see ''intestinal metaplasia'' section. | |||
#Pseudopyloric metaplasia; gastric body looks like gastric antrum. | |||
#*Characterized by ''foveolar hyperplasia''. | |||
#Cell loss without replacement. | |||
#*Clue is deep inflammation in the body. | |||
=Non-neoplastic disease= | =Non-neoplastic disease= | ||
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- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY. | - NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY. | ||
</pre> | </pre> | ||
==Autoimmune metaplastic atrophic gastritis== | ==Autoimmune metaplastic atrophic gastritis== | ||