Difference between revisions of "Odontogenic tumours and cysts"

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==Keratocystic odontogenic tumour==
==Keratocystic odontogenic tumour==
*Abbreviated ''KOT''.
{{Main|Keratocystic odontogenic tumour}}
*Previously known as ''odontogenic keratocyst'', abbreviated ''OKC''.<ref name=pmid18353202>{{Cite journal  | last1 = Madras | first1 = J. | last2 = Lapointe | first2 = H. | title = Keratocystic odontogenic tumour: reclassification of the odontogenic keratocyst from cyst to tumour. | journal = J Can Dent Assoc | volume = 74 | issue = 2 | pages = 165-165h | month = Mar | year = 2008 | doi =  | PMID = 18353202 }}</ref>
===General===
*May be associated with ''[[nevoid basal cell carcinoma syndrome]]''.
 
====Clinical====
Features:<ref name=pmid17928730>{{Cite journal  | last1 = Habibi | first1 = A. | last2 = Saghravanian | first2 = N. | last3 = Habibi | first3 = M. | last4 = Mellati | first4 = E. | last5 = Habibi | first5 = M. | title = Keratocystic odontogenic tumor: a 10-year retrospective study of 83 cases in an Iranian population. | journal = J Oral Sci | volume = 49 | issue = 3 | pages = 229-35 | month = Sep | year = 2007 | doi =  | PMID = 17928730 }}</ref>
*Most common presentation: swelling.
 
===Gross===
*Location: usually mandible.
*May mimic [[ameloblastoma]] radiologically.
 
===Microscopic===
Features: <ref>Thompson LDR. Head and neck pathology - (Foundations in diagnostic pathology). Goldblum JR, Ed.. Churchill Livingstone. 2006. ISBN 0-443-06960-3.</ref>
*Stratified epithelium (resembling squamous epithelium) with:
**"Ribbon-like appearance" - '''important'''.
***Typically 8-10 cell layers thick - with relatively uniform thickness.
***Lacks rete ridges. 
**Palisaded basal cell layer.
*Parakeratosis (keratinized cells with nuclei) - '''key feature'''.
*Artefactual separation of epithelium from the basement membrane.
 
DDx:
*Odontogenic cyst.
**Orthokeratinized odontogenic cyst<ref name=pmid21062939>{{Cite journal  | last1 = Macdonald-Jankowski | first1 = DS. | title = Orthokeratinized odontogenic cyst: a systematic review. | journal = Dentomaxillofac Radiol | volume = 39 | issue = 8 | pages = 455-67 | month = Dec | year = 2010 | doi = 10.1259/dmfr/19728573 | PMID =  }}</ref> - usu. [[dentigerous cyst]] - has [[orthokeratosis]] instead of [[parakeratosis]].
***Orthokeratosis = keratinized cells no nuclei; parakeratosis = keratinized cell with nuclei.
 
Images:
*[http://commons.wikimedia.org/wiki/File:Keratocystic_odontogenic_tumour_-_2_-_intermed_mag.jpg KOT - intermed. mag. (WC)].
*[http://commons.wikimedia.org/wiki/File:Keratocystic_odontogenic_tumour_-_2_-_very_high_mag.jpg KOT - very high mag. (WC)].
*[http://commons.wikimedia.org/wiki/File:Keratocystic_odontogenic_tumour_-_intermed_mag.jpg KOT - another case - intermed. mag. (WC)]
*[http://commons.wikimedia.org/wiki/File:Keratocystic_odontogenic_tumour1.jpg KOT - poor quality (WC)].
*[http://commons.wikimedia.org/wiki/File:Keratocystic_odontogenic_tumour2.jpg KOT - showing artefactual clefting - poor quality (WC)].
*[http://ars.els-cdn.com/content/image/1-s2.0-S0968605305000992-gr5.jpg KOT (els-cdn.com)].<ref>URL: [http://www.sciencedirect.com/science/article/pii/S0968605305000992#fig5 http://www.sciencedirect.com/science/article/pii/S0968605305000992#fig5]. Accessed on: 11 March 2013.</ref>


==Ameloblastoma==
==Ameloblastoma==
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