Difference between revisions of "Lymph node pathology"
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===General=== | ===General=== | ||
*Lymphadenopathy associated with a skin lesion - '''key feature'''. | *Lymphadenopathy associated with a skin lesion - '''key feature'''. | ||
*May be benign or malignant (e.g. T-cell lymphoma). | *May be benign ''or'' malignant (e.g. T-cell lymphoma). | ||
===Microscopic=== | ===Microscopic=== | ||
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*Plasma cells (medulla). | *Plasma cells (medulla). | ||
*Eosinophils. | *Eosinophils. | ||
Histiocytes & special histiocytes: | Histiocytes & special histiocytes: | ||
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**Need IHC to identify definitively. | **Need IHC to identify definitively. | ||
IHC | DDx: | ||
*[[Metastatic]] [[malignant melanoma]] - pigmented cells have nuclear atypia, not histiocytes. | |||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Dermatopathic_lymphadenopathy_-_low_mag.jpg DL - low mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Dermatopathic_lymphadenopathy_-_intermed_mag.jpg DL - intermed. mag. (WC)]. | |||
===IHC=== | |||
*Interdigitating dendritic cells: S100 +ve, CD1a -ve. | *Interdigitating dendritic cells: S100 +ve, CD1a -ve. | ||
*Langerhans cells: S100 +ve, CD1a +ve. | *Langerhans cells: S100 +ve, CD1a +ve. | ||