Difference between revisions of "Stomach"

Line 768:

Review paper: PMID 16950858.

==~~Familial~~ gastric ~~carcinoma~~==

==Hereditary gastric cancer==

*Signet ring carcinoma - associated with E-~~cadherin~~ (CDH1<ref>{{OMIM|192090}}</ref>~~) mutation~~.<ref name=pmid9537325>{{Cite journal | last1 = Guilford | first1 = P. | last2 = Hopkins | first2 = J. | last3 = Harraway | first3 = J. | last4 = McLeod | first4 = M. | last5 = McLeod | first5 = N. | last6 = Harawira | first6 = P. | last7 = Taite | first7 = H. | last8 = Scoular | first8 = R. | last9 = Miller | first9 = A. | title = E-cadherin germline mutations in familial gastric cancer. | journal = Nature | volume = 392 | issue = 6674 | pages = 402-5 | month = Mar | year = 1998 | doi = 10.1038/32918 | PMID = 9537325 }}</ref>

Several syndrome are associated with gastric cancer:<ref>{{Cite journal | last1 = Sereno | first1 = M. | last2 = Aguayo | first2 = C. | last3 = Guillén Ponce | first3 = C. | last4 = Gómez-Raposo | first4 = C. | last5 = Zambrana | first5 = F. | last6 = Gómez-López | first6 = M. | last7 = Casado | first7 = E. | title = Gastric tumours in hereditary cancer syndromes: clinical features, molecular biology and strategies for prevention. | journal = Clin Transl Oncol | volume = 13 | issue = 9 | pages = 599-610 | month = Sep | year = 2011 | doi = | PMID = 21865131 }}</ref>

{| class="wikitable sortable"

! Disease

! Gene

! Histology

! Other

|-

| Hereditary diffuse gastric cancer (HDGC) syndrome

| CDH1 (E-cadherin)<ref>{{OMIM|192090}}</ref>

| diffuse - more specifically [[signet ring cell carcinoma]]

| most important; assoc. [[invasive lobular carcinoma]]<ref name=pmid9537325>{{Cite journal | last1 = Guilford | first1 = P. | last2 = Hopkins | first2 = J. | last3 = Harraway | first3 = J. | last4 = McLeod | first4 = M. | last5 = McLeod | first5 = N. | last6 = Harawira | first6 = P. | last7 = Taite | first7 = H. | last8 = Scoular | first8 = R. | last9 = Miller | first9 = A. | title = E-cadherin germline mutations in familial gastric cancer. | journal = Nature | volume = 392 | issue = 6674 | pages = 402-5 | month = Mar | year = 1998 | doi = 10.1038/32918 | PMID = 9537325 }}</ref>

|-

| [[Lynch syndrome]]

| several

| ?

| colorectal carcinoma, endometrial carcinoma

|-

| [[Familial adenomatous polyposis]]

| APC

| ?

| adenomatous polyps

|-

| [[Peutz-Jeghers syndrome]]

| STK11

| ?

| stomach hamartomas - not precursor

|-

| [[Li-Fraumeni syndrome]]

| TP53 (p53)

| ?

|-

| Hereditary breast and ovarian cancer

| BRCA1

|

|}

==Gastric adenocarcinoma==

Difference between revisions of "Stomach"

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@@ Line 768: / Line 768: @@
 Review paper: PMID 16950858.
-==Familial gastric carcinoma==
+==Hereditary gastric cancer==
-*Signet ring carcinoma - associated with E-cadherin (CDH1<ref>{{OMIM|192090}}</ref>) mutation.<ref name=pmid9537325>{{Cite journal  | last1 = Guilford | first1 = P. | last2 = Hopkins | first2 = J. | last3 = Harraway | first3 = J. | last4 = McLeod | first4 = M. | last5 = McLeod | first5 = N. | last6 = Harawira | first6 = P. | last7 = Taite | first7 = H. | last8 = Scoular | first8 = R. | last9 = Miller | first9 = A. | title = E-cadherin germline mutations in familial gastric cancer. | journal = Nature | volume = 392 | issue = 6674 | pages = 402-5 | month = Mar | year = 1998 | doi = 10.1038/32918 | PMID = 9537325 }}</ref>
+Several syndrome are associated with gastric cancer:<ref>{{Cite journal  | last1 = Sereno | first1 = M. | last2 = Aguayo | first2 = C. | last3 = Guillén Ponce | first3 = C. | last4 = Gómez-Raposo | first4 = C. | last5 = Zambrana | first5 = F. | last6 = Gómez-López | first6 = M. | last7 = Casado | first7 = E. | title = Gastric tumours in hereditary cancer syndromes: clinical features, molecular biology and strategies for prevention. | journal = Clin Transl Oncol | volume = 13 | issue = 9 | pages = 599-610 | month = Sep | year = 2011 | doi =  | PMID = 21865131 }}</ref>
+{| class="wikitable sortable"
+! Disease
+! Gene
+! Histology
+! Other
+|-
+| Hereditary diffuse gastric cancer (HDGC) syndrome
+| CDH1 (E-cadherin)<ref>{{OMIM|192090}}</ref>
+| diffuse - more specifically [[signet ring cell carcinoma]]
+| most important; assoc. [[invasive lobular carcinoma]]<ref name=pmid9537325>{{Cite journal  | last1 = Guilford | first1 = P. | last2 = Hopkins | first2 = J. | last3 = Harraway | first3 = J. | last4 = McLeod | first4 = M. | last5 = McLeod | first5 = N. | last6 = Harawira | first6 = P. | last7 = Taite | first7 = H. | last8 = Scoular | first8 = R. | last9 = Miller | first9 = A. | title = E-cadherin germline mutations in familial gastric cancer. | journal = Nature | volume = 392 | issue = 6674 | pages = 402-5 | month = Mar | year = 1998 | doi = 10.1038/32918 | PMID = 9537325 }}</ref>
+|-
+| [[Lynch syndrome]]
+| several
+| ?
+| colorectal carcinoma, endometrial carcinoma
+|-
+| [[Familial adenomatous polyposis]]
+| APC
+| ?
+| adenomatous polyps
+|-
+| [[Peutz-Jeghers syndrome]]
+| STK11
+| ?
+| stomach hamartomas - not precursor
+|-
+| [[Li-Fraumeni syndrome]]
+| TP53 (p53)
+| ?
+| ?
+|-
+| Hereditary breast and ovarian cancer
+| BRCA1
+|
+|
+|}
 ==Gastric adenocarcinoma==