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Difference between revisions of "Dermatologic neoplasms"
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===General=== | ===General=== | ||
*Benign skin lesion. | *Benign skin lesion. | ||
**Occasionally malignant.<ref name=pmid16882695/> | |||
*Should not be confused with ''cylindroma'' ([[adenoid cystic carcinoma]]). | *Should not be confused with ''cylindroma'' ([[adenoid cystic carcinoma]]). | ||
*May be related to ''[[eccrine spiradenoma]]''.<ref name=pmid6302142>{{Cite journal | last1 = Gerber | first1 = JE. | last2 = Descalzi | first2 = ME. | title = Eccrine spiradenoma and dermal cylindroma. | journal = J Cutan Pathol | volume = 10 | issue = 1 | pages = 73-8 | month = Feb | year = 1983 | doi = | PMID = 6302142 }}</ref><ref name=pmid8936072>{{Cite journal | last1 = Lee | first1 = MW. | last2 = Kelly | first2 = JW. | title = Dermal cylindroma and eccrine spiradenoma. | journal = Australas J Dermatol | volume = 37 | issue = 1 | pages = 48-9 | month = Feb | year = 1996 | doi = | PMID = 8936072 }}</ref> | *May be related to ''[[eccrine spiradenoma]]''.<ref name=pmid6302142>{{Cite journal | last1 = Gerber | first1 = JE. | last2 = Descalzi | first2 = ME. | title = Eccrine spiradenoma and dermal cylindroma. | journal = J Cutan Pathol | volume = 10 | issue = 1 | pages = 73-8 | month = Feb | year = 1983 | doi = | PMID = 6302142 }}</ref><ref name=pmid8936072>{{Cite journal | last1 = Lee | first1 = MW. | last2 = Kelly | first2 = JW. | title = Dermal cylindroma and eccrine spiradenoma. | journal = Australas J Dermatol | volume = 37 | issue = 1 | pages = 48-9 | month = Feb | year = 1996 | doi = | PMID = 8936072 }}</ref> | ||
May be familial:<ref name=pmid16882695/> | |||
*Familial cylindromatosis (autosomal dominant). | |||
*Brook–Spiegler syndrome. | |||
===Gross=== | |||
*Classically scalp - usually head and neck or face. | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features:<ref name=pmid16882695/> | ||
*Nests of basilar cells that fit together like a jigsaw puzzle. | *Nests of basilar cells that fit together like a jigsaw puzzle. | ||
**The borders of the nests are opposed and undulate. | **The borders of the nests are opposed and undulate. | ||
*Cells nests surrounded by a band of hyaline (i.e. glassy, eosinophilic, acellular) material ~ 2X thickness of a basilar cell - '''key feature'''. | *Cells nests surrounded by a band of hyaline (i.e. glassy, eosinophilic, acellular) material ~ 2X thickness of a basilar cell - '''key feature'''. | ||
**This is basement membrane. | |||
DDx: | DDx: | ||
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**[http://commons.wikimedia.org/wiki/File:Dermal_cylindroma_intermed_mag_deep.jpg Dermal cylindroma - high mag. (WC)]. | **[http://commons.wikimedia.org/wiki/File:Dermal_cylindroma_intermed_mag_deep.jpg Dermal cylindroma - high mag. (WC)]. | ||
*www: | *www: | ||
**[http://jcp.bmj.com/content/60/2/145/F7.large.jpg Dermal cylindroma (bmj.com)].<ref name=pmid16882695>{{Cite journal | last1 = Obaidat | first1 = NA. | last2 = Alsaad | first2 = KO. | last3 = Ghazarian | first3 = D. | title = Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat glands. | journal = J Clin Pathol | volume = 60 | issue = 2 | pages = 145-59 | month = Feb | year = 2007 | doi = 10.1136/jcp.2006.041608 | PMID = 16882695 | PMC = 1860616 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860616/?tool=pubmed }} | **[http://jcp.bmj.com/content/60/2/145/F7.large.jpg Dermal cylindroma (bmj.com)].<ref name=pmid16882695>{{Cite journal | last1 = Obaidat | first1 = NA. | last2 = Alsaad | first2 = KO. | last3 = Ghazarian | first3 = D. | title = Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat glands. | journal = J Clin Pathol | volume = 60 | issue = 2 | pages = 145-59 | month = Feb | year = 2007 | doi = 10.1136/jcp.2006.041608 | PMID = 16882695 | PMC = 1860616 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860616/?tool=pubmed }}</ref> | ||
</ | |||
===Stains=== | |||
*PAS +ve (basement membrane).<ref name=pmid16882695/> | |||
==Keratoacanthoma== | ==Keratoacanthoma== | ||