Difference between revisions of "Endometrial carcinoma"

Line 32:

==Subtypes - overview==

They are commonly grouped based on clinicopathologic features:<ref name=pmid21309259>{{Cite journal | last1 = Lim | first1 = D. | last2 = Oliva | first2 = E. | title = Nonendometrioid endometrial carcinomas. | journal = Semin Diagn Pathol | volume = 27 | issue = 4 | pages = 241-60 | month = Nov | year = 2010 | doi = | PMID = 21309259 }}</ref>

They are commonly grouped based on clinicopathologic features:<ref name=pmid21309259>{{Cite journal | last1 = Lim | first1 = D. | last2 = Oliva | first2 = E. | title = Nonendometrioid endometrial carcinomas. | journal = Semin Diagn Pathol | volume = 27 | issue = 4 | pages = 241-60 | month = Nov | year = 2010 | doi = | PMID = 21309259 }}</ref><ref name=Ref_GP241>{{Ref GP|241}}</ref>

#Type I:

{| class="wikitable sortable"

~~#*Histologic types:~~

!Feature

~~#**Endometrioid (most common).~~

!Type I

~~#**Mucinous.~~

!Type II

~~#*Clinical characteristics: premenopausal, estrogen excess.~~

|-

~~#Group II:~~

|Histologic types

#*Histologic types:

|[[endometrioid endometrial carcinoma]], [[mucinous endometrial carcinoma]]

~~#**Serous~~ carcinoma.

|[[serous carcinoma of the endometrium]], [[clear cell carcinoma of the endometrium]]

~~#**Clear~~ cell carcinoma.

|-

#*Clinical characteristics: postmenopausal, no estrogen excess, poor ~~prognosis.~~

|Clinical <br>characteristics

| premneopausal, estrogen excess, [[endometrial hyperplasia]]

~~The most common as a list:~~

| postmenopausal, no estrogen excess, atrophic endometrium

~~#Endometrioid - '''most common'''~~, ~~patient typically is 55-65 years old and obese.~~

|-

~~#Serous - patients classically older than endometrioid subtype, arise in atrophic endometrium.~~

|Prognosis

~~#Clear cell.~~

| good

| poor

|-

|Genetic <br>abnormalities

| microsatellite instability, PTEN & KRAS mutations

| p53 mutations

|}

==Grading (FIGO)==

Difference between revisions of "Endometrial carcinoma"

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@@ Line 32: / Line 32: @@
 ==Subtypes - overview==
-They are commonly grouped based on clinicopathologic features:<ref name=pmid21309259>{{Cite journal  | last1 = Lim | first1 = D. | last2 = Oliva | first2 = E. | title = Nonendometrioid endometrial carcinomas. | journal = Semin Diagn Pathol | volume = 27 | issue = 4 | pages = 241-60 | month = Nov | year = 2010 | doi =  | PMID = 21309259 }}</ref>
+They are commonly grouped based on clinicopathologic features:<ref name=pmid21309259>{{Cite journal  | last1 = Lim | first1 = D. | last2 = Oliva | first2 = E. | title = Nonendometrioid endometrial carcinomas. | journal = Semin Diagn Pathol | volume = 27 | issue = 4 | pages = 241-60 | month = Nov | year = 2010 | doi =  | PMID = 21309259 }}</ref><ref name=Ref_GP241>{{Ref GP|241}}</ref>
-#Type I:
+{| class="wikitable sortable"
-#*Histologic types:
+!Feature
-#**Endometrioid (most common).
+!Type I
-#**Mucinous.
+!Type II
-#*Clinical characteristics: premenopausal, estrogen excess.
+|-
-#Group II:
+|Histologic types
-#*Histologic types:
+|[[endometrioid endometrial carcinoma]], [[mucinous endometrial carcinoma]]
-#**Serous carcinoma.
+|[[serous carcinoma of the endometrium]], [[clear cell carcinoma of the endometrium]]
-#**Clear cell carcinoma.
+|-
-#*Clinical characteristics: postmenopausal, no estrogen excess, poor prognosis.
+|Clinical <br>characteristics
+| premneopausal, estrogen excess, [[endometrial hyperplasia]]
-The most common as a list:
+| postmenopausal, no estrogen excess, atrophic endometrium
-#Endometrioid - '''most common''', patient typically is 55-65 years old and obese.
+|-
-#Serous - patients classically older than endometrioid subtype, arise in atrophic endometrium.
+|Prognosis
-#Clear cell.
+| good
+| poor
+|-
+|Genetic <br>abnormalities
+| microsatellite instability, PTEN & KRAS mutations
+| p53 mutations
+|}
 ==Grading (FIGO)==