Difference between revisions of "Basics"

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See: ''[[Lymph node]]'' article for a detailed description of cell types in a lymph node.
See: ''[[Lymph node]]'' article for a detailed description of cell types in a lymph node.


===Signet ring cells===
===Signet ring cell carcinoma===
Definition:
{{Main|Signet ring cell carcinoma}}
*Signet ring cells resemble [http://www.engravingarts.com/sales/LVX2.jpg signet rings (image)].
*It has been said that there are two types of pathologists... those that have missed SRCs ''and'' those that will miss SRCs.
**They contain a large amount of mucin, which pushes the nucleus to the cell periphery. The pool of mucin in a signet ring cell mimics the appearance of a finger hole and the nucleus mimics the appearance of the face of the ring in profile.


Microscopy:
Microscopic:
*Typically 2-3x the size of a lymphocyte.
*Cells resemble signet rings:
**They contain a large amount of mucin, which pushes the nucleus to the cell periphery.
**The pool of mucin in a signet ring cell mimics the appearance of a finger hole.
**The nucleus mimics the appearance of the face of the ring in profile.
*Cells typically 2-3x the size of a lymphocyte.
**Smaller than the typical adipocyte.
**Smaller than the typical adipocyte.
*Often have a [http://en.wikipedia.org/wiki/File:Crescent.svg cresentic-shaped] nucleus, or ovoid nucleus.
*Often have a crescent-shaped ''or'' ovoid nucleus.
**Capillaries sectioned on their lumen have endothelial cells-- the nuclei of these are more spindled.
**Capillaries sectioned on their lumen have endothelial cells -- the nuclei of these are more spindled.
*SRCs are usually close to friend (another SRC)
*SRCs are usually close to friend -- another SRC.
**This helps differentiate SRCs from capillaries sectioned on their lumen.
**This helps differentiate SRCs from capillaries sectioned on their lumen.
*The mucin is often clear on H&E... but maybe eosinophilic.
*The mucin is often clear on H&E... but maybe eosinophilic.
DDx:
*Fat atrophy.


Stains:
Stains:
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Images:
Images:
*[http://www.engravingarts.com/sales/LVX2.jpg Signet rings (engravingarts.com)].
*[http://commons.wikimedia.org/wiki/File:Signet_ring_cells_5.jpg SRCs (H&E) by Nephron (WC)].
*[http://commons.wikimedia.org/wiki/File:Signet_ring_cells_5.jpg SRCs (H&E) by Nephron (WC)].
*[http://commons.wikimedia.org/wiki/File:Gastric_signet_ring_cell_carcinoma_histopatholgy_(2)_PAS_stain.jpg SRC AL-PAS stain (WC)].
*[http://commons.wikimedia.org/wiki/File:Gastric_signet_ring_cell_carcinoma_histopatholgy_(2)_PAS_stain.jpg SRC AL-PAS stain (WC)].
*[http://commons.wikimedia.org/wiki/File:Gastric_signet_ring_cell_carcinoma_histopatholgy_(1).jpg SRC H&E stain (WC)].
*[http://commons.wikimedia.org/wiki/File:Gastric_signet_ring_cell_carcinoma_histopatholgy_(1).jpg SRC H&E stain (WC)].
Comment:
*It has been said that there are two types of pathologists... those that have missed SRCs ''and'' those that will miss SRCs.


===Necrosis===
===Necrosis===
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