Difference between revisions of "Cardiomyopathy"
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'''Cardiomyopathy''', abbreviated as '''CM''', is a domain of cardiology and [[forensic pathology]] | '''Cardiomyopathy''', abbreviated as '''CM''', is a domain of cardiology ''and'' [[forensic pathology]], as many cardiomyopathies can lead to sudden death. | ||
==Overview== | ==Overview== | ||
Types<ref> | Types<ref name=Ref_PBoD601>{{Ref PBoD|601}}</ref> | ||
#Dilated cardiomyopathy - most common ~ 90% | #Dilated cardiomyopathy - most common ~ 90% | ||
#Hypertrophic cardiomyopathy | #Hypertrophic cardiomyopathy | ||
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==Dilated cardiomyopathy== | ==Dilated cardiomyopathy== | ||
===General=== | ===General=== | ||
*Classic cause of sudden death in young athletes.<ref>{{cite journal |author=Gojanovic B, Feihl F, Gremion G, Waeber B |title=[Sudden death in young athletes] |language=German |journal=Praxis (Bern 1994) |volume=96 |issue=6 |pages=189-98 |year=2007 |month=February |pmid=17330410 |doi= |url=}}</ref> | *Classic cause of sudden death in young athletes.<ref name=pmid17330410>{{cite journal |author=Gojanovic B, Feihl F, Gremion G, Waeber B |title=[Sudden death in young athletes] |language=German |journal=Praxis (Bern 1994) |volume=96 |issue=6 |pages=189-98 |year=2007 |month=February |pmid=17330410 |doi= |url=}}</ref> | ||
*Most common of the cardiomyopathies. | *Most common of the cardiomyopathies. | ||
Causes: | Causes: | ||
*Myocarditis - leading cause, usually viral.<ref name=pmid19017683> | *Myocarditis - leading cause, usually viral.<ref name=pmid19017683>{{cite journal |author=Luk A, Ahn E, Soor GS, Butany J |title=Dilated cardiomyopathy: a review |journal=J. Clin. Pathol. |volume=62 |issue=3 |pages=219–25 |year=2009 |month=March |pmid=19017683 |doi=10.1136/jcp.2008.060731 |url=}}</ref> | ||
*Familial ~ 30% - can be AD with variable penetrance, AR, X-linked. | *Familial ~ 30% - can be AD with variable penetrance, AR, X-linked. | ||
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===Microscopic=== | ===Microscopic=== | ||
Features:<ref> | Features:<ref name=Ref_PBoD601-3>{{Ref PBoD|601-3}}</ref> | ||
*Myocardial fibre has increased transverse size (40 micrometres). | *Myocardial fibre has increased transverse size (40 micrometres). | ||
**Normal myocardial fibre width = 15 micrometres. | **Normal myocardial fibre width = 15 micrometres. | ||
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===Gross features=== | ===Gross features=== | ||
Gross:<ref name=emedicine1612324>URL: [http://emedicine.medscape.com/article/1612324-overview http://emedicine.medscape.com/article/1612324-overview]</ref> | Gross:<ref name=emedicine1612324>URL: [http://emedicine.medscape.com/article/1612324-overview http://emedicine.medscape.com/article/1612324-overview].</ref> | ||
*RV wall thinning/replacement with fat. | *RV wall thinning/replacement with fat. | ||
**Especially fat where fat is ''not'' usually seen - posterior RV wall, RVOT. | **Especially fat where fat is ''not'' usually seen - posterior RV wall, RVOT. | ||