Difference between revisions of "Medical liver disease"

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===Microscopic===
===Microscopic===
Features:
Features:
*Pink globules in zone 1.
*Pink globules in zone 1 (periportal).
**Globules ''not'' seen in children.
**Globules ''not'' seen in children.
**May ''not'' be present in late stage (cirrhotic).
**May ''not'' be present in late stage (cirrhotic).
**Best seen on [[PAS-diastase]].
**Best seen on [[PASD stain]].
**Can be seen on H&E -- if one looks carefully.
**Can be seen on H&E -- if one looks carefully.


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===IHC===
===IHC===
*IHC for A1-AT exists - but isn't useful according to one paper.<Ref name=pmid3512609>{{Cite journal  | last1 = Theaker | first1 = JM. | last2 = Fleming | first2 = KA. | title = Alpha-1-antitrypsin and the liver: a routine immunohistological screen. | journal = J Clin Pathol | volume = 39 | issue = 1 | pages = 58-62 | month = Jan | year = 1986 | doi =  | PMID = 3512609 }}</ref>
*A1-AT globules +ve.<Ref name=pmid3512609>{{Cite journal  | last1 = Theaker | first1 = JM. | last2 = Fleming | first2 = KA. | title = Alpha-1-antitrypsin and the liver: a routine immunohistological screen. | journal = J Clin Pathol | volume = 39 | issue = 1 | pages = 58-62 | month = Jan | year = 1986 | doi =  | PMID = 3512609 }}</ref>
**Blood serum values used. (???)


=Other=
=Other=
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