Difference between revisions of "Neuromuscular pathology"
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(→Drug-induced rhabdomyolysis: more) |
(→Microscopic: more) |
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| Line 509: | Line 509: | ||
Features: | Features: | ||
*Muscle [[necrosis]]. | *Muscle [[necrosis]]. | ||
**Fibre collapse | **Fibre collapse = increased staining on [[H&E stain|H&E]], [[HPS stain|HPS]]. | ||
**Karyolysis - loss/decrease of nuclei. | |||
**Macrophage (phagocytosis) clean-up = pale moth-eaten appearance (seen well on [[PAS stain|PAS]]). | |||
*No inflammation. | *No inflammation. | ||
*No perifascicular atrophy. | *No perifascicular atrophy. | ||
| Line 515: | Line 517: | ||
Images: | Images: | ||
*[http://path.upmc.edu/cases/case184/micro.html Drug-induced rhabdomyolysis - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case184/micro.html Drug-induced rhabdomyolysis - several images (upmc.edu)]. | ||
===Stains=== | |||
*PAS +ve fibres (macrophages). | |||
===IHC=== | |||
*CD45 -ve (no lymphocytes). | |||
===EM=== | |||
*Negative for [[tubuloreticular inclusions]]. | |||
**Seen in viral infections. | |||
==Nerve stuff== | ==Nerve stuff== | ||