Difference between revisions of "Nasopharyngeal angiofibroma"

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#redirect [[Head_and_neck_pathology#Nasopharyngeal_angiofibroma]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Nasopharyngeal_angiofibroma_-_2_-_high_mag.jpg
| Width      =
| Caption    = Nasopharyngeal angiofibroma. [[H&E stain]].
| Synonyms  =
| Micro      = fibroblastic cells with plump (near cuboidal) nuclei, fibrous stroma, abundant capillaries
| Subtypes  =
| LMDDx      =
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[head and neck pathology|head and neck]] - nasopharynx
| Assdx      =
| Syndromes  =
| Clinicalhx = male, adolescents young to adults, frequent nose bleeds
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    =
| Tx        = surgical resection
}}
'''Nasopharyngeal angiofibroma''' is a benign lesion of the [[head and neck pathology|head and neck]].


==General==
*Classically adolescent males with recurrent nose bleeds.
**Age range 8-41 in one series of 162 cases.<ref name=pmid24222212>{{Cite journal  | last1 = Huang | first1 = Y. | last2 = Liu | first2 = Z. | last3 = Wang | first3 = J. | last4 = Sun | first4 = X. | last5 = Yang | first5 = L. | last6 = Wang | first6 = D. | title = Surgical management of juvenile nasopharyngeal angiofibroma: analysis of 162 cases from 1995 to 2012. | journal = Laryngoscope | volume = 124 | issue = 8 | pages = 1942-6 | month = Aug | year = 2014 | doi = 10.1002/lary.24522 | PMID = 24222212 }}
</ref>
*Can be subtyped by location into three groups.<ref name=pmid23332298>{{Cite journal  | last1 = Yi | first1 = Z. | last2 = Fang | first2 = Z. | last3 = Lin | first3 = G. | last4 = Lin | first4 = C. | last5 = Xiao | first5 = W. | last6 = Li | first6 = Z. | last7 = Cheng | first7 = J. | last8 = Zhou | first8 = A. | title = Nasopharyngeal angiofibroma: a concise classification system and appropriate treatment options. | journal = Am J Otolaryngol | volume = 34 | issue = 2 | pages = 133-41 | month =  | year =  | doi = 10.1016/j.amjoto.2012.10.004 | PMID = 23332298 }}</ref>
==Microscopic==
Features:<ref name=Ref_Klatt144>{{Ref Klatt|144}}</ref>
*Fibroblastic cells with plump (near cuboidal) nuclei.
*Fibrous stroma.
*Abundant capillaries.
===Images===
<gallery>
Image: Nasopharyngeal angiofibroma - intermed mag.jpg | Intermed. mag.
Image: Nasopharyngeal angiofibroma - high mag.jpg | High mag.
Image: Nasopharyngeal angiofibroma - very high mag.jpg | Very high mag.
</gallery>
<gallery>
Image: Nasopharyngeal angiofibroma - 2 - high mag.jpg | High mag.
</gallery>
==See also==
*[[Head and neck pathology]].
==References==
{{Reflist|1}}
[[Category:Head and neck pathology]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Latest revision as of 06:25, 14 January 2015

Nasopharyngeal angiofibroma
Diagnosis in short

Nasopharyngeal angiofibroma. H&E stain.
LM fibroblastic cells with plump (near cuboidal) nuclei, fibrous stroma, abundant capillaries
Site head and neck - nasopharynx
Clinical history male, adolescents young to adults, frequent nose bleeds
Prevalence uncommon
Prognosis benign
Treatment surgical resection

Nasopharyngeal angiofibroma is a benign lesion of the head and neck.

General

  • Classically adolescent males with recurrent nose bleeds.
    • Age range 8-41 in one series of 162 cases.[1]
  • Can be subtyped by location into three groups.[2]

Microscopic

Features:[3]

  • Fibroblastic cells with plump (near cuboidal) nuclei.
  • Fibrous stroma.
  • Abundant capillaries.

Images

  • Intermed. mag.

  • High mag.

  • Very high mag.

  • High mag.

See also

References

  1. ↑ Huang, Y.; Liu, Z.; Wang, J.; Sun, X.; Yang, L.; Wang, D. (Aug 2014). "Surgical management of juvenile nasopharyngeal angiofibroma: analysis of 162 cases from 1995 to 2012.". Laryngoscope 124 (8): 1942-6. doi:10.1002/lary.24522. PMID 24222212.
  2. ↑ Yi, Z.; Fang, Z.; Lin, G.; Lin, C.; Xiao, W.; Li, Z.; Cheng, J.; Zhou, A.. "Nasopharyngeal angiofibroma: a concise classification system and appropriate treatment options.". Am J Otolaryngol 34 (2): 133-41. doi:10.1016/j.amjoto.2012.10.004. PMID 23332298.
  3. ↑ Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 144. ISBN 978-1416002741.
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