Multicystic dysplastic kidney: Difference between revisions
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*Most common cause of abdominal mass in newborns.<ref name=emed_mrd>URL: [http://emedicine.medscape.com/article/982560-overview http://emedicine.medscape.com/article/982560-overview]. Accessed on: 4 January 2012.</ref> | *Most common cause of abdominal mass in newborns.<ref name=emed_mrd>URL: [http://emedicine.medscape.com/article/982560-overview http://emedicine.medscape.com/article/982560-overview]. Accessed on: 4 January 2012.</ref> | ||
*May be unilateral or involve only part of a kidney.<ref name=Ref_Klatt237>{{Ref Klatt|237}}</ref> | *May be unilateral or involve only part of a kidney.<ref name=Ref_Klatt237>{{Ref Klatt|237}}</ref> | ||
*Usually not associated with a genetic syndrome.<ref name=pmid33252759/> | |||
Etiology: | Etiology: | ||
* | *Embryological malformation.<ref name=pmid33252759/> | ||
**Normal development: renal collecting system forms when ''ureteric bud'' (which grows from cloaca) meets the ''renal blastema'' (the kidney parenchyma precursor). | |||
**In MCDK ''ureteric bud'' and ''renal blastema'' fail to meet. | |||
==Gross== | ==Gross== | ||
*Kidney has multiple large cysts | *Kidney has multiple large cysts of differing sizes. | ||
*Normal renal pelvis is absent.<ref name=pmid33252759/> | |||
DDx: | DDx: | ||
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==Microscopic== | ==Microscopic== | ||
Features:<ref name=Ref_Klatt237>{{Ref Klatt|237}}</ref><ref name=pmid33252759/> | Features:<ref name=Ref_Klatt237>{{Ref Klatt|237}}</ref><ref name=pmid33252759/> | ||
*Cystic spaces of variable size. | *Cystic spaces of variable size, lined by cuboidal cells. | ||
*Fibrous stroma. | *Fibrous stroma. | ||
*Islands of cartilage. | *Islands of cartilage. | ||
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Note: | Note: | ||
*Cysts do not communicate with one another.<ref name=pmid33252759>{{ | *Cysts do not communicate with one another.<ref name=pmid33252759>{{cite journal |authors=Meyers ML, Treece AL, Brown BP, Vemulakonda VM |title=Imaging of fetal cystic kidney disease: multicystic dysplastic kidney versus renal cystic dysplasia |journal=Pediatr Radiol |volume=50 |issue=13 |pages=1921–1933 |date=December 2020 |pmid=33252759 |doi=10.1007/s00247-020-04755-5 |url=}}</ref> | ||
==See also== | ==See also== | ||