Small cell carcinoma of the lung: Difference between revisions

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| Caption    = Lung small cell carcinoma. [[H&E stain]].
| Caption    = Lung small cell carcinoma. [[H&E stain]].
| Synonyms  =
| Synonyms  =
| Micro      = stippled chromatin, high [[NC ratio]] with scant basophilic cytoplasm, typically small cells (~2x [[RBC]] diameter), +/-nuclear moulding, nuclei with smudgy appearance ([[Azzopardi phenomenon]]), necrosis, [[mitoses]]
| Micro      = stippled chromatin, high [[NC ratio]] with scant basophilic cytoplasm, typically small cells (~2x [[RBC]] diameter), +/-nuclear moulding, nuclei with smudgy appearance ([[Azzopardi phenomenon]]), necrosis, mitoses
| Subtypes  = histology: large cell neuroendocrine carcinoma (LCNEC); molecular subtypes: ASCL1, NEUROD1, POU2F3, YAP1
| Subtypes  = histology: large cell neuroendocrine carcinoma (LCNEC); molecular subtypes: ASCL1, NEUROD1, POU2F3, YAP1
| LMDDx      = poorly differentiated [[adenocarcinoma of the lung]], [[atypical carcinoid]], [[lung carcinoid]], metastatic [[small cell carcinoma]], [[lymphoma]], other [[small round blue cell tumours]]
| LMDDx      = poorly differentiated [[adenocarcinoma of the lung]], [[atypical carcinoid]], [[lung carcinoid]], metastatic [[small cell carcinoma]], [[lymphoma]], other [[small round blue cell tumours]] (e.g [[Ewing sarcoma]], [[NUT carcinoma]])
| Stains    =  
| Stains    =  
| IHC        = chromogranin +ve, synaptophysin +ve, CD56 +ve, NSE +ve, TTF-1 +ve, Ki-67 (>50%)
| IHC        = chromogranin +ve, synaptophysin +ve, CD56 +ve, NSE +ve, TTF-1 +ve, Ki-67 (>50%)
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! IHC grouping
! IHC grouping
! Prevalence
! Prevalence
! Other IHC
! Notes
! Notes
! Other IHC
|-
|-
|ASCL1+ / NeuroD1-
|ASCL1 +ve / NeuroD1 -ve
|41%
|41%
|TTF-1 +ve
|
|
|TTF1+
|-
|-
|ASCL1+ / NeuroD1+
|ASCL1 +ve / NeuroD1 +ve
|37%
|37%
|TTF-1 +ve
|
|
|TTF1+
|-
|-
|ASCL1- / NeuroD1+
|ASCL1 -ve / NeuroD1 +ve
|8%
|8%
|TTF-1 +ve
|
|
|TTF1+
|-
|-
|ASCL1- / NeuroD1-
|ASCL1 -ve / NeuroD1 -ve
|14%
|14%
|includes all POU2F3 cases which are ~9% of small cell carcinoma
|TTF-1 -ve
|TTF1-
|includes all POU2F3 +ve cases which are ~9% of small cell carcinoma
|}
|}


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