Difference between revisions of "Lymphoepithelioma-like carcinoma"
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'''Lymphoepithelioma-like carcinoma''', abbreviated '''LELC''', is a | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Lymphoepithelioma-like_carcinoma_-_high_mag.jpg | |||
| Width = | |||
| Caption = Lymphoepithelioma-like carcinoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = clusters of cohesive squamoid cells with abundant dense cytoplasm, central nuclei +/- small/indistinct nucleoli, surrounded by a prominent lymphoid component | |||
| Subtypes = (considered a subtype of [[squamous carcinoma]]) | |||
| LMDDx = [[squamous cell carcinoma of the skin]], [[lymphoma]] (non-Hodgkin), [[medullary carcinoma]], [[nasopharyngeal carcinoma]] (head & neck) | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[skin]] and elsewhere | |||
| Assdx = [[EBV]] infection (dependent on anatomical site) | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Lymphoepithelioma-like carcinoma''', abbreviated '''LELC''', is a rare, poorly differentiated, malignant epithelial tumour. | |||
It can be considered a subtype of [[squamous carcinoma]] ([[AKA]] squamous cell carcinoma);<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970297-2#back-bib45 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970297-2#back-bib45]. Accessed on: 26 May 2011.</ref> however, some advocate it be considered a separate entity.<ref name=pmid11147469>{{Cite journal | last1 = Skinner | first1 = NE. | last2 = Horowitz | first2 = RI. | last3 = Majmudar | first3 = B. | title = Lymphoepithelioma-like carcinoma of the uterine cervix. | journal = South Med J | volume = 93 | issue = 10 | pages = 1024-7 | month = Oct | year = 2000 | doi = | PMID = 11147469 }}</ref> | |||
==General== | ==General== | ||
It is thought to be related to ''[[nasopharyngeal carcinoma]]'' ([[AKA]] lymphoepithelioma).<ref name=pmid17347662>{{Cite journal | last1 = Mayer | first1 = EK. | last2 = Beckley | first2 = I. | last3 = Winkler | first3 = MH. | title = Lymphoepithelioma-like carcinoma of the urinary bladder--diagnostic and clinical implications. | journal = Nat Clin Pract Urol | volume = 4 | issue = 3 | pages = 167-71 | month = Mar | year = 2007 | doi = 10.1038/ncpuro0725 | PMID = 17347662 }}</ref><ref name=dermcdlib_lelc>URL: [http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/arsenovic.html http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/arsenovic.html]. Accessed on: 11 May 2011.</ref> | It is thought to be related to ''[[nasopharyngeal carcinoma]]'' ([[AKA]] lymphoepithelioma).<ref name=pmid17347662>{{Cite journal | last1 = Mayer | first1 = EK. | last2 = Beckley | first2 = I. | last3 = Winkler | first3 = MH. | title = Lymphoepithelioma-like carcinoma of the urinary bladder--diagnostic and clinical implications. | journal = Nat Clin Pract Urol | volume = 4 | issue = 3 | pages = 167-71 | month = Mar | year = 2007 | doi = 10.1038/ncpuro0725 | PMID = 17347662 }}</ref><ref name=dermcdlib_lelc>URL: [http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/arsenovic.html http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/arsenovic.html]. Accessed on: 11 May 2011.</ref> | ||
Epidemiology: | Epidemiology: | ||
| Line 8: | Line 42: | ||
Etiology: | Etiology: | ||
*Associated with [[EBV]],<ref name=pmid17347662/> like | *Associated with [[EBV]],<ref name=pmid17347662/> in most anatomical sites (nasopharynx, [[stomach]], lung, thymus, salivary gland). | ||
**Exceptions: | |||
***Skin and [[uterine cervix]].<ref name=pmid7726142>{{Cite journal | last1 = Lespagnard | first1 = L. | last2 = Cochaux | first2 = P. | last3 = Larsimont | first3 = D. | last4 = Degeyter | first4 = M. | last5 = Velu | first5 = T. | last6 = Heimann | first6 = R. | title = Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction. | journal = Am J Clin Pathol | volume = 103 | issue = 4 | pages = 449-52 | month = Apr | year = 1995 | doi = | PMID = 7726142 }}</ref> | |||
****The exception to the exception: there is a case report of EBV in LELC of the skin.<ref name=pmid20227583>{{Cite journal | last1 = Aoki | first1 = R. | last2 = Mitsui | first2 = H. | last3 = Harada | first3 = K. | last4 = Kawamura | first4 = T. | last5 = Shibagaki | first5 = N. | last6 = Tsukamoto | first6 = K. | last7 = Murata | first7 = S. | last8 = Shimada | first8 = S. | title = A case of lymphoepithelioma-like carcinoma of the skin associated with Epstein-Barr virus infection. | journal = J Am Acad Dermatol | volume = 62 | issue = 4 | pages = 681-4 | month = Apr | year = 2010 | doi = 10.1016/j.jaad.2008.07.024 | PMID = 20227583 }}</ref> | |||
***[[Lymphoepithelioma-like carcinoma of the urinary bladder|Urinary bladder]].<ref name=pmid21383609>{{Cite journal | last1 = Williamson | first1 = SR. | last2 = Zhang | first2 = S. | last3 = Lopez-Beltran | first3 = A. | last4 = Shah | first4 = RB. | last5 = Montironi | first5 = R. | last6 = Tan | first6 = PH. | last7 = Wang | first7 = M. | last8 = Baldridge | first8 = LA. | last9 = MacLennan | first9 = GT. | title = Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. | journal = Am J Surg Pathol | volume = 35 | issue = 4 | pages = 474-83 | month = Apr | year = 2011 | doi = 10.1097/PAS.0b013e31820f709e | PMID = 21383609 }}</ref> | |||
Notes: | |||
*The (macroscopic, microscopic, epidemiologic, prognostic) features of LELC are very similar to ''medullary carcinoma'' -- EBV status is one differentiator.<ref name=pmid7726142>{{Cite journal | last1 = Lespagnard | first1 = L. | last2 = Cochaux | first2 = P. | last3 = Larsimont | first3 = D. | last4 = Degeyter | first4 = M. | last5 = Velu | first5 = T. | last6 = Heimann | first6 = R. | title = Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction. | journal = Am J Clin Pathol | volume = 103 | issue = 4 | pages = 449-52 | month = Apr | year = 1995 | doi = | PMID = 7726142 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
* Clusters of cohesive squamoid cells with: | * Clusters of cohesive squamoid cells with: | ||
** | **Abundant dense cytoplasm. | ||
**Central nuclei +/- small/indistinct nucleoli. | **Central nuclei +/- small/indistinct nucleoli. | ||
**Surrounded by a prominent lymphoid component - '''key feature'''. | **Surrounded by a prominent lymphoid component - '''key feature'''. | ||
DDx: | DDx: | ||
*[[Squamous cell carcinoma of the skin]]. | |||
*[[Lymphoma]]. | *[[Lymphoma]]. | ||
*[[Medullary carcinoma]]. | |||
*[[Nasopharyngeal carcinoma]] - H&N lesion. | |||
Images: | ===Images=== | ||
<gallery> | |||
Image: Lymphoepithelioma-like carcinoma - very low mag.jpg | LELC - very low mag. | |||
Image:Lymphoepithelioma-like_carcinoma_-_low_mag.jpg | LELC - low mag. (WC) | |||
Image: Lymphoepithelioma-like carcinoma - intermed mag.jpg | LELC - intermed. mag. | |||
Image:Lymphoepithelioma-like_carcinoma_-_high_mag.jpg | LELC - high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/2.jpg LELC (dermatology.cdlib.org)].<ref name=dermcdlib_lelc/> | *[http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/2.jpg LELC (dermatology.cdlib.org)].<ref name=dermcdlib_lelc/> | ||
| Line 26: | Line 77: | ||
*[[Nasopharyngeal carcinoma]]. | *[[Nasopharyngeal carcinoma]]. | ||
*[[EBV]]. | *[[EBV]]. | ||
*[[Squamous cell carcinoma]]. | |||
*[[Lymphoepithelioma-like carcinoma of the urinary bladder]]. | |||
==References== | ==References== | ||
Latest revision as of 00:37, 30 September 2015
| Lymphoepithelioma-like carcinoma | |
|---|---|
| Diagnosis in short | |
 Lymphoepithelioma-like carcinoma. H&E stain. | |
|
| |
| LM | clusters of cohesive squamoid cells with abundant dense cytoplasm, central nuclei +/- small/indistinct nucleoli, surrounded by a prominent lymphoid component |
| Subtypes | (considered a subtype of squamous carcinoma) |
| LM DDx | squamous cell carcinoma of the skin, lymphoma (non-Hodgkin), medullary carcinoma, nasopharyngeal carcinoma (head & neck) |
| Site | skin and elsewhere |
|
| |
| Associated Dx | EBV infection (dependent on anatomical site) |
| Prevalence | rare |
Lymphoepithelioma-like carcinoma, abbreviated LELC, is a rare, poorly differentiated, malignant epithelial tumour.
It can be considered a subtype of squamous carcinoma (AKA squamous cell carcinoma);[1] however, some advocate it be considered a separate entity.[2]
General
It is thought to be related to nasopharyngeal carcinoma (AKA lymphoepithelioma).[3][4]
Epidemiology:
- Common in Inuit and some Asians.[5]
Etiology:
- Associated with EBV,[3] in most anatomical sites (nasopharynx, stomach, lung, thymus, salivary gland).
- Exceptions:
- Skin and uterine cervix.[6]
- The exception to the exception: there is a case report of EBV in LELC of the skin.[7]
- Urinary bladder.[8]
- Skin and uterine cervix.[6]
- Exceptions:
Notes:
- The (macroscopic, microscopic, epidemiologic, prognostic) features of LELC are very similar to medullary carcinoma -- EBV status is one differentiator.[6]
Microscopic
Features:
- Clusters of cohesive squamoid cells with:
- Abundant dense cytoplasm.
- Central nuclei +/- small/indistinct nucleoli.
- Surrounded by a prominent lymphoid component - key feature.
DDx:
- Squamous cell carcinoma of the skin.
- Lymphoma.
- Medullary carcinoma.
- Nasopharyngeal carcinoma - H&N lesion.
Images
LELC - very low mag.
LELC - low mag. (WC)
LELC - intermed. mag.
LELC - high mag. (WC)
www:
See also
- Nasopharyngeal carcinoma.
- EBV.
- Squamous cell carcinoma.
- Lymphoepithelioma-like carcinoma of the urinary bladder.
References
- ↑ URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970297-2#back-bib45. Accessed on: 26 May 2011.
- ↑ Skinner, NE.; Horowitz, RI.; Majmudar, B. (Oct 2000). "Lymphoepithelioma-like carcinoma of the uterine cervix.". South Med J 93 (10): 1024-7. PMID 11147469.
- ↑ 3.0 3.1 Mayer, EK.; Beckley, I.; Winkler, MH. (Mar 2007). "Lymphoepithelioma-like carcinoma of the urinary bladder--diagnostic and clinical implications.". Nat Clin Pract Urol 4 (3): 167-71. doi:10.1038/ncpuro0725. PMID 17347662.
- ↑ 4.0 4.1 URL: http://dermatology.cdlib.org/148/case_presentations/lymphoepithelioma/arsenovic.html. Accessed on: 11 May 2011.
- ↑ URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970335-7. Accessed on: 11 May 2011.
- ↑ 6.0 6.1 Lespagnard, L.; Cochaux, P.; Larsimont, D.; Degeyter, M.; Velu, T.; Heimann, R. (Apr 1995). "Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction.". Am J Clin Pathol 103 (4): 449-52. PMID 7726142.
- ↑ Aoki, R.; Mitsui, H.; Harada, K.; Kawamura, T.; Shibagaki, N.; Tsukamoto, K.; Murata, S.; Shimada, S. (Apr 2010). "A case of lymphoepithelioma-like carcinoma of the skin associated with Epstein-Barr virus infection.". J Am Acad Dermatol 62 (4): 681-4. doi:10.1016/j.jaad.2008.07.024. PMID 20227583.
- ↑ Williamson, SR.; Zhang, S.; Lopez-Beltran, A.; Shah, RB.; Montironi, R.; Tan, PH.; Wang, M.; Baldridge, LA. et al. (Apr 2011). "Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features.". Am J Surg Pathol 35 (4): 474-83. doi:10.1097/PAS.0b013e31820f709e. PMID 21383609.