Renal cell carcinoma with fibromyomatous stroma: Difference between revisions
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''Renal cell carcinoma with leiomyomatous stroma'' redirects here. | ''Renal cell carcinoma with leiomyomatous stroma'' redirects here. | ||
==General== | |||
*Rare tumour: 12 in >500 renal cell carcinomas with clear cells.<ref name=pmid36592877/> | |||
==Microscopic== | ==Microscopic== | ||
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===Comparison between some renal tumours with clear cells=== | ===Comparison between some renal tumours with clear cells=== | ||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
!Tumour | !Tumour | ||
!CA9 | |||
!CK7 | !CK7 | ||
!CD10 | !CD10 | ||
!CK34betaE12 (K903) | !CK34betaE12 (K903) | ||
!GPNMB | ![[GPNMB]] | ||
|- | |- | ||
|Clear cell renal cell carcinoma | |Clear cell renal cell carcinoma | ||
| +ve box-like (complete membrane) | |||
| -ve (may be focal) | | -ve (may be focal) | ||
| +ve | | +ve | ||
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|- | |- | ||
|Clear cell papillary renal cell tumour | |Clear cell papillary renal cell tumour | ||
| +ve cup-like | |||
| +ve (diffuse) | | +ve (diffuse) | ||
| -ve | | -ve | ||
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| -ve<ref name=pmid37661807>{{cite journal |authors=Li H, Argani P, Halper-Stromberg E, Lotan TL, Merino MJ, Reuter VE, Matoso A |title=Positive GPNMB Immunostaining Differentiates Renal Cell Carcinoma With Fibromyomatous Stroma Associated With TSC1/2/MTOR Alterations From Others |journal=Am J Surg Pathol |volume=47 |issue=11 |pages=1267–1273 |date=November 2023 |pmid=37661807 |doi=10.1097/PAS.0000000000002117 |url=}}</ref> | | -ve<ref name=pmid37661807>{{cite journal |authors=Li H, Argani P, Halper-Stromberg E, Lotan TL, Merino MJ, Reuter VE, Matoso A |title=Positive GPNMB Immunostaining Differentiates Renal Cell Carcinoma With Fibromyomatous Stroma Associated With TSC1/2/MTOR Alterations From Others |journal=Am J Surg Pathol |volume=47 |issue=11 |pages=1267–1273 |date=November 2023 |pmid=37661807 |doi=10.1097/PAS.0000000000002117 |url=}}</ref> | ||
|- | |- | ||
|ELOC-mutated renal cell carcinoma | |ELOC-mutated renal cell carcinoma | ||
| +ve box-like | |||
| +ve | | +ve | ||
| +ve | | +ve | ||
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| -ve | | -ve | ||
|- | |- | ||
| | |Renal cell carcinoma with fibromyomatous stroma | ||
| +ve box-like or cup-like<ref name=pmid36611378>{{cite journal |authors=Stanca S, Boldrini L, Erba PA, Faviana P |title=Are Renal Cell Carcinoma with Fibromyomatous Stroma (RCC-FMS) and Thyroid-like Follicular Carcinoma of the Kidney (TLFCK) Really Independent Variants? |journal=Diagnostics (Basel) |volume=13 |issue=1 |pages= |date=December 2022 |pmid=36611378 |pmc=9818596 |doi=10.3390/diagnostics13010086 |url=}}</ref> | |||
| +ve | | +ve | ||
| +ve | | +ve | ||
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|- | |- | ||
|} | |} | ||
==Molecular== | ==Molecular== | ||
*[[Renal neoplasms with TSC/mTOR pathway mutations|TSC/mTOR pathway mutation]].<ref name=pmid36592877/> | *[[Renal neoplasms with TSC/mTOR pathway mutations|TSC/mTOR pathway mutation]].<ref name=pmid36592877/> | ||
**A somewhat non-specific finding as [[Renal neoplasms with TSC/mTOR pathway mutations|several renal tumours (with a different morphology) have TSC/mTOR pathway mutations]]. | |||
==Sign out== | |||
===Molecular lacking=== | |||
<pre> | |||
Right Kidney, Radical Nephrectomy: | |||
- RENAL CELL CARCINOMA with clear cells, cysts and leiomyomatous stroma, see comment. | |||
-- Margin clear. | |||
-- Please see synoptic report for details. | |||
Comment: | |||
The tumour stains as follows: | |||
POSITIVE: CD10 (moderate), EMA (patchy), CK7 (diffuse), PAX8 (diffuse). | |||
NEGATIVE: CK34betaE12, CK20. | |||
The differential diagnosis includes: (1) clear cell renal cell carcinoma, (2) RCC with a mTOR pathway mutation, and (3) ELOC-mutated RCC. | |||
</pre> | |||
==See also== | ==See also== | ||