Eosinophilic vacuolated tumour: Difference between revisions
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| Image = High-grade oncocytic renal tumour -- high mag.jpg | | Image = High-grade oncocytic renal tumour -- high mag.jpg | ||
| Width = | | Width = | ||
| Caption = Micrograph of | | Caption = Micrograph of an eosinophilic vacuolated tumour. [[H&E stain]]. | ||
| Synonyms = high-grade oncocytic | | Synonyms = high-grade oncocytic tumour | ||
| Micro = abundant oncocytic cytoplasm with prominent intracytoplasmic vacuoles, | | Micro = abundant oncocytic cytoplasm with prominent intracytoplasmic vacuoles, | ||
round nuclei, [[prominent nucleoli]] ([[ISUP nucleolar grade]] 3), no perinuclear halos | round nuclei, [[prominent nucleoli]] ([[ISUP nucleolar grade]] 3), no perinuclear halos | ||
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| IHC = PAX8 +ve, CD117 +ve, CD10 +ve, SDHB +ve, TFE3 -ve | | IHC = PAX8 +ve, CD117 +ve, CD10 +ve, SDHB +ve, TFE3 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = TSC1 or TSC2 mutation | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
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'''Eosinophilic vacuolated tumour''', abbreviated '''EVT''', is a [[kidney tumour]] type currently not recognized by the WHO classification as per the 2016 Blue Book. | '''Eosinophilic vacuolated tumour''', abbreviated '''EVT''', is a [[kidney tumour]] type currently not recognized by the WHO classification as per the 2016 Blue Book. | ||
It was previously known as ''' | It was previously known as '''high-grade oncocytic tumour''', abbreviated '''HOT'''.<ref name=pmid34521993>{{cite journal |authors=Farcaş M, Gatalica Z, Trpkov K, Swensen J, Zhou M, Alaghehbandan R, Williamson SR, Magi-Galluzzi C, Gill AJ, Tretiakova M, Lopez JI, Montiel DP, Sperga M, Comperat E, Brimo F, Yilmaz A, Siadat F, Sangoi A, Gao Y, Ptákova N, Kuthi L, Pivovarcikova K, Rogala J, Agaimy A, Hartmann A, Fraune C, Rychly B, Hurnik P, Durcansky D, Bonert M, Gakis G, Michal M, Hora M, Hes O |title=Eosinophilic vacuolated tumor (EVT) of kidney demonstrates sporadic TSC/MTOR mutations: next-generation sequencing multi-institutional study of 19 cases |journal=Mod Pathol |volume= |issue= |pages= |date=September 2021 |pmid=34521993 |doi=10.1038/s41379-021-00923-6 |url=}}</ref> | ||
==General== | ==General== | ||
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*TFE3 -ve. | *TFE3 -ve. | ||
*[[CD117]] +ve (9 of 14 cases). | *[[CD117]] +ve (9 of 14 cases). | ||
Others: | |||
*CD56 +ve.{{fact}} | |||
**Typically negative in [[renal oncocytoma]]. | |||
==Molecular== | |||
*TSC1 or TSC2 mutation - see [[renal neoplasms with TSC/mTOR pathway mutations]]. | |||
==See also== | ==See also== | ||