Angiomyolipoma: Difference between revisions

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*Abundant [[blood vessel]]s.

~~Note~~:

Notes:

*May have melanin pigment - occasionally extensive.<ref name=pmid26118214>{{Cite journal | last1 = Reddy | first1 = R. | last2 = Lewin | first2 = JR. | last3 = Shenoy | first3 = V. | title = Pigmented Epithelioid Angiomyolipoma of the Kidney. | journal = J Miss State Med Assoc | volume = 56 | issue = 4 | pages = 92-4 | month = Apr | year = 2015 | doi = | PMID = 26118214 }}</ref><ref name=pmid23136579>{{Cite journal | last1 = Chang | first1 = H. | last2 = Jung | first2 = W. | last3 = Kang | first3 = Y. | last4 = Jung | first4 = WY. | title = Pigmented perivascular epithelioid cell tumor (PEComa) of the kidney: a case report and review of the literature. | journal = Korean J Pathol | volume = 46 | issue = 5 | pages = 499-502 | month = Oct | year = 2012 | doi = 10.4132/KoreanJPathol.2012.46.5.499 | PMID = 23136579 }}</ref>

*May involve lymph nodes - case reports.<ref name=pmid2294869>{{cite journal |authors=Ro JY, Ayala AG, el-Naggar A, Grignon DJ, Hogan SF, Howard DR |title=Angiomyolipoma of kidney with lymph node involvement. DNA flow cytometric analysis |journal=Arch Pathol Lab Med |volume=114 |issue=1 |pages=65–7 |date=January 1990 |pmid=2294869 |doi= |url=}}</ref><ref name=pmid12696187>{{cite journal |vauthor=Shiga Y, Tsutsumi M, Suzuki K, Ishikawa S, Shimogama T |title=Angiomyolipoma with regional lymph node involvement: a case report and literature review |journal=Hinyokika Kiyo |volume=49 |issue=2 |pages=81–6 |date=February 2003 |pmid=12696187 |doi= |url=}}</ref>

DDx:

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====Micro====

The section show a circumscribed tumour composed of muscle-like tissue and adipose tissue with prominent muscular blood vessels. Rare nuclear enlargement is seen. No ~~signficant~~ nuclear atypia is appreciated. Mitotic activity is not apparent.

The section show a circumscribed tumour composed of muscle-like tissue and adipose tissue with prominent muscular blood vessels. Rare nuclear enlargement is seen. No significant nuclear atypia is appreciated. Mitotic activity is not apparent.

===Biopsy===

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NEGATIVE: CK (pooled).

</pre>

=====Micro=====

The sections show a tumour composed of spindle cells in a fascicular arrangement with scant adipose tissue and prominent muscular blood vessels. Rare nuclear enlargement is seen. No significant nuclear atypia is appreciated. Mitotic activity is not apparent. No renal parenchyma is identified.

===Epithelioid===

Comment:

Epithelioid change in angiomyolipoma can be associated with aggressive behaviour; follow-up is recommended.

====Micro====

The sections show a tumour composed of spindle cells in a fascicular arrangement with ~~scant~~ adipose tissue and prominent muscular blood vessels. ~~Rare nuclear enlargement~~ is ~~seen. No significant nuclear~~ atypia ~~is appreciated~~. Mitotic activity is not apparent. ~~No renal parenchyma~~ is ~~identified~~.

The sections show a tumour composed of spindle cells in a fascicular arrangement with abundant adipose tissue and prominent muscular blood vessels. A focal epithelioid subcomponent is present and has moderate atypia. Mitotic activity is not readily apparent. The epithelioid component is completely removed in the plane-of-section.

==See also==

@@ Line 72: / Line 72: @@
 *Abundant [[blood vessel]]s.
-Note:
+Notes:
 *May have melanin pigment - occasionally extensive.<ref name=pmid26118214>{{Cite journal  | last1 = Reddy | first1 = R. | last2 = Lewin | first2 = JR. | last3 = Shenoy | first3 = V. | title = Pigmented Epithelioid Angiomyolipoma of the Kidney. | journal = J Miss State Med Assoc | volume = 56 | issue = 4 | pages = 92-4 | month = Apr | year = 2015 | doi =  | PMID = 26118214 }}</ref><ref name=pmid23136579>{{Cite journal  | last1 = Chang | first1 = H. | last2 = Jung | first2 = W. | last3 = Kang | first3 = Y. | last4 = Jung | first4 = WY. | title = Pigmented perivascular epithelioid cell tumor (PEComa) of the kidney: a case report and review of the literature. | journal = Korean J Pathol | volume = 46 | issue = 5 | pages = 499-502 | month = Oct | year = 2012 | doi = 10.4132/KoreanJPathol.2012.46.5.499 | PMID = 23136579 }}</ref>
+*May involve lymph nodes - case reports.<ref name=pmid2294869>{{cite journal |authors=Ro JY, Ayala AG, el-Naggar A, Grignon DJ, Hogan SF, Howard DR |title=Angiomyolipoma of kidney with lymph node involvement. DNA flow cytometric analysis |journal=Arch Pathol Lab Med |volume=114 |issue=1 |pages=65–7 |date=January 1990 |pmid=2294869 |doi= |url=}}</ref><ref name=pmid12696187>{{cite journal |vauthor=Shiga Y, Tsutsumi M, Suzuki K, Ishikawa S, Shimogama T |title=Angiomyolipoma with regional lymph node involvement: a case report and literature review |journal=Hinyokika Kiyo |volume=49 |issue=2 |pages=81–6 |date=February 2003 |pmid=12696187 |doi= |url=}}</ref>
 DDx:
@@ Line 183: / Line 184: @@
 ====Micro====
-The section show a circumscribed tumour composed of muscle-like tissue and adipose tissue with prominent muscular blood vessels.  Rare nuclear enlargement is seen. No signficant nuclear atypia is appreciated. Mitotic activity is not apparent.
+The section show a circumscribed tumour composed of muscle-like tissue and adipose tissue with prominent muscular blood vessels.  Rare nuclear enlargement is seen. No significant nuclear atypia is appreciated. Mitotic activity is not apparent.
 ===Biopsy===
@@ Line 206: / Line 207: @@
 NEGATIVE: CK (pooled).
 </pre>
+=====Micro=====
+The sections show a tumour composed of spindle cells in a fascicular arrangement with scant adipose tissue and prominent muscular blood vessels.  Rare nuclear enlargement is seen. No significant nuclear atypia is appreciated. Mitotic activity is not apparent. No renal parenchyma is identified.
+===Epithelioid===
+Comment:
+Epithelioid change in angiomyolipoma can be associated with aggressive behaviour; follow-up is recommended.
 ====Micro====
-The sections show a tumour composed of spindle cells in a fascicular arrangement with scant adipose tissue and prominent muscular blood vessels.  Rare nuclear enlargement is seen. No significant nuclear atypia is appreciated. Mitotic activity is not apparent. No renal parenchyma is identified.
+The sections show a tumour composed of spindle cells in a fascicular arrangement with abundant adipose tissue and prominent muscular blood vessels. A focal epithelioid subcomponent is present and has moderate atypia. Mitotic activity is not readily apparent. The epithelioid component is completely removed in the plane-of-section.
 ==See also==

Angiomyolipoma: Difference between revisions

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