Nasopharyngeal carcinoma: Difference between revisions
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Nasopharyngeal carcinoma - alt -- high mag.jpg | ||
| Width = | | Width = | ||
| Caption = Nasopharyngeal carcinoma. [[H&E stain]]. | | Caption = Nasopharyngeal carcinoma. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = nasopharyngeal-type undifferentiated carcinoma, non-keratining nasopharyngeal carcinoma undifferentiated type | ||
| Micro = Cohesive typical (squamoid) cells (abundant dense eosinophilic cytoplasm, central nuclei +/- small/indistinct nucleoli), prominent lymphoid component | | Micro = Cohesive typical (squamoid) cells (abundant dense eosinophilic cytoplasm, central nuclei +/- small/indistinct nucleoli), prominent lymphoid component | ||
| Subtypes = keratinizing SCC; nonkeratinizing carcinoma, differentiated; nonkeratinizing carcinoma, undifferentiated; basaloid SCC | | Subtypes = keratinizing SCC; nonkeratinizing carcinoma, differentiated; nonkeratinizing carcinoma, undifferentiated; basaloid SCC | ||
| LMDDx = [[HPV-associated head and neck squamous cell carcinoma]], [[squamous cell carcinoma of the head and neck]] | | LMDDx = [[HPV-associated head and neck squamous cell carcinoma]], [[squamous cell carcinoma of the head and neck]], [[sinonasal undifferentiated carcinoma]] (SNUC) | ||
| Stains = | | Stains = | ||
| IHC = p16 -ve, LMP-1 -ve/+ve | | IHC = p16 -ve, LMP-1 -ve/+ve | ||
| EM = | | EM = | ||
| Molecular = EBER +ve | | Molecular = [[EBER]] +ve | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
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*[[HPV-associated head and neck squamous cell carcinoma]]. | *[[HPV-associated head and neck squamous cell carcinoma]]. | ||
*[[Squamous cell carcinoma of the head and neck]]. | *[[Squamous cell carcinoma of the head and neck]]. | ||
*[[Sinonasal undifferentiated carcinoma]] (SNUC). | |||
===Images=== | ===Images=== | ||
====Case 1==== | |||
<gallery> | |||
Image: Nasopharyngeal carcinoma -- extremely low mag.jpg | NPC - very low mag. (WC) | |||
Image: Nasopharyngeal carcinoma -- very low mag.jpg | NPC - very low mag. (WC) | |||
Image: Nasopharyngeal carcinoma -- low mag.jpg | NPC - low mag. (WC) | |||
Image: Nasopharyngeal carcinoma -- intermed mag.jpg | NPC - intermed. mag. (WC) | |||
Image: Nasopharyngeal carcinoma -- high mag.jpg | NPC - high mag. (WC) | |||
Image: Nasopharyngeal carcinoma - alt -- high mag.jpg | NPC - high mag. (WC) | |||
Image: Nasopharyngeal carcinoma -- very high mag.jpg | NPC - very high mag. (WC) | |||
</gallery> | |||
====Case 2==== | |||
<gallery> | <gallery> | ||
Image:Lymphoepithelioma_met_to_LN_6.jpg | Nasopharyngeal carcinoma - in a LN - intermed. mag. (WC) | Image:Lymphoepithelioma_met_to_LN_6.jpg | Nasopharyngeal carcinoma - in a LN - intermed. mag. (WC) | ||
</gallery> | </gallery> | ||
www | ====www==== | ||
*[http://en.wikipedia.org/wiki/File:Lymphoepithelioma_met_to_LN_4.jpg Nasopharyngeal carcinoma - in a LN - low mag. (WP)]. | *[http://en.wikipedia.org/wiki/File:Lymphoepithelioma_met_to_LN_4.jpg Nasopharyngeal carcinoma - in a LN - low mag. (WP)]. | ||
*[http://en.wikipedia.org/wiki/File:Lymphoepithelioma_met_to_LN_2.jpg Nasopharyngeal carcinoma - in a LN - high mag. (WP)]. | *[http://en.wikipedia.org/wiki/File:Lymphoepithelioma_met_to_LN_2.jpg Nasopharyngeal carcinoma - in a LN - high mag. (WP)]. | ||
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==Molecular== | ==Molecular== | ||
*EBER +ve.<ref name=pmid11913680/> | *[[EBER]] +ve.<ref name=pmid11913680/> | ||
===Images=== | |||
<gallery> | |||
Image: Nasopharyngeal carcinoma - EBER -- very low mag.jpg | NPC - EBER - very low mag. (WC) | |||
Image: Nasopharyngeal carcinoma - EBER -- low mag.jpg | NPC - EBER - low mag. (WC) | |||
Image: Nasopharyngeal carcinoma - EBER -- high mag.jpg | NPC - EBER - high mag. (WC) | |||
</gallery> | |||
==See also== | ==See also== | ||