Difference between revisions of "Myoepithelial carcinoma"

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'''Myoepithelial carcinoma''', abbreviated '''MECA''' a rare malignant [[salivary gland]] tumour.<ref name=pmid25970687>{{Cite journal  | last1 = Kong | first1 = M. | last2 = Drill | first2 = EN. | last3 = Morris | first3 = L. | last4 = West | first4 = L. | last5 = Klimstra | first5 = D. | last6 = Gonen | first6 = M. | last7 = Ghossein | first7 = R. | last8 = Katabi | first8 = N. | title = Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases. | journal = Am J Surg Pathol | volume = 39 | issue = 7 | pages = 931-8 | month = Jul | year = 2015 | doi = 10.1097/PAS.0000000000000452 | PMID = 25970687 }}</ref> It is the malignant counterpart of [[myoepithelioma]].
'''Myoepithelial carcinoma''', abbreviated '''MECA''' a rare malignant [[salivary gland]] tumour.<ref name=pmid25970687>{{Cite journal  | last1 = Kong | first1 = M. | last2 = Drill | first2 = EN. | last3 = Morris | first3 = L. | last4 = West | first4 = L. | last5 = Klimstra | first5 = D. | last6 = Gonen | first6 = M. | last7 = Ghossein | first7 = R. | last8 = Katabi | first8 = N. | title = Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases. | journal = Am J Surg Pathol | volume = 39 | issue = 7 | pages = 931-8 | month = Jul | year = 2015 | doi = 10.1097/PAS.0000000000000452 | PMID = 25970687 }}</ref>  
 
It is the malignant counterpart of [[myoepithelioma]] and also known as '''malignant myoepithelioma'''.<ref name=pmid9797738>{{Cite journal  | last1 = McCluggage | first1 = WG. | last2 = Primrose | first2 = WJ. | last3 = Toner | first3 = PG. | title = Myoepithelial carcinoma (malignant myoepithelioma) of the parotid gland arising in a pleomorphic adenoma. | journal = J Clin Pathol | volume = 51 | issue = 7 | pages = 552-6 | month = Jul | year = 1998 | doi =  | PMID = 9797738 }}</ref>


==General==
==General==
*Rare.
*Rare.
*Often misdiagnosed as "benign".<ref name=pmid30789358/>


==Microscopic==
==Microscopic==
Features:
Features:<ref name=pmid30789358>{{Cite journal  | last1 = Xu | first1 = B. | last2 = Mneimneh | first2 = W. | last3 = Torrence | first3 = DE. | last4 = Higgins | first4 = K. | last5 = Klimstra | first5 = D. | last6 = Ghossein | first6 = R. | last7 = Katabi | first7 = N. | title = Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall. | journal = Am J Surg Pathol | volume =  | issue =  | pages =  | month = Feb | year = 2019 | doi = 10.1097/PAS.0000000000001218 | PMID = 30789358 }}</ref>
*Myoepithelial cells - may be cytologically very bland.
*Myoepithelial cells - may be cytologically very bland.
*+/-Overt features of malignancy (necrosis, nuclear atypia, infiltrative growth, proliferation).
*Hypocellular centre (hyaline or myxoid) and hypercellular periphery.
*Hypocellular centre (hyaline or myxoid) and hypercellular periphery.
*Pushing border ("expansile nodular lobulated pattern").
*No ductal structures.
*No ductal structures.
Note:
*Overt features of malignancy (necrosis, nuclear atypia, infiltrative growth, proliferation) absent.


DDx:
DDx:
Line 19: Line 25:


==Molecular==
==Molecular==
*Fusions with PLAG1.<ref name=pmid29084941>{{Cite journal  | last1 = Dalin | first1 = MG. | last2 = Katabi | first2 = N. | last3 = Persson | first3 = M. | last4 = Lee | first4 = KW. | last5 = Makarov | first5 = V. | last6 = Desrichard | first6 = A. | last7 = Walsh | first7 = LA. | last8 = West | first8 = L. | last9 = Nadeem | first9 = Z. | title = Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions. | journal = Nat Commun | volume = 8 | issue = 1 | pages = 1197 | month = 10 | year = 2017 | doi = 10.1038/s41467-017-01178-z | PMID = 29084941 }}</ref>
*+/-Fusions with PLAG1 gene.<ref name=pmid29084941>{{Cite journal  | last1 = Dalin | first1 = MG. | last2 = Katabi | first2 = N. | last3 = Persson | first3 = M. | last4 = Lee | first4 = KW. | last5 = Makarov | first5 = V. | last6 = Desrichard | first6 = A. | last7 = Walsh | first7 = LA. | last8 = West | first8 = L. | last9 = Nadeem | first9 = Z. | title = Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions. | journal = Nat Commun | volume = 8 | issue = 1 | pages = 1197 | month = 10 | year = 2017 | doi = 10.1038/s41467-017-01178-z | PMID = 29084941 }}</ref>
*+/-EWSR1 gene rearrangement.<ref>{{Cite journal  | last1 = Thway | first1 = K. | last2 = Bown | first2 = N. | last3 = Miah | first3 = A. | last4 = Turner | first4 = R. | last5 = Fisher | first5 = C. | title = Rhabdoid Variant of Myoepithelial Carcinoma, with EWSR1 Rearrangement: Expanding the Spectrum of EWSR1-Rearranged Myoepithelial Tumors. | journal = Head Neck Pathol | volume = 9 | issue = 2 | pages = 273-9 | month = Jun | year = 2015 | doi = 10.1007/s12105-014-0556-2 | PMID = 24993038 }}</ref>


==See also==
==See also==

Latest revision as of 01:50, 19 March 2019

Myoepithelial carcinoma, abbreviated MECA a rare malignant salivary gland tumour.[1]

It is the malignant counterpart of myoepithelioma and also known as malignant myoepithelioma.[2]

General

  • Rare.
  • Often misdiagnosed as "benign".[3]

Microscopic

Features:[3]

  • Myoepithelial cells - may be cytologically very bland.
  • Hypocellular centre (hyaline or myxoid) and hypercellular periphery.
  • Pushing border ("expansile nodular lobulated pattern").
  • No ductal structures.

Note:

  • Overt features of malignancy (necrosis, nuclear atypia, infiltrative growth, proliferation) absent.

DDx:

IHC

  • CAM5.2 +ve.

Molecular

  • +/-Fusions with PLAG1 gene.[4]
  • +/-EWSR1 gene rearrangement.[5]

See also

References

  1. ↑ Kong, M.; Drill, EN.; Morris, L.; West, L.; Klimstra, D.; Gonen, M.; Ghossein, R.; Katabi, N. (Jul 2015). "Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases.". Am J Surg Pathol 39 (7): 931-8. doi:10.1097/PAS.0000000000000452. PMID 25970687.
  2. ↑ McCluggage, WG.; Primrose, WJ.; Toner, PG. (Jul 1998). "Myoepithelial carcinoma (malignant myoepithelioma) of the parotid gland arising in a pleomorphic adenoma.". J Clin Pathol 51 (7): 552-6. PMID 9797738.
  3. ↑ 3.0 3.1 Xu, B.; Mneimneh, W.; Torrence, DE.; Higgins, K.; Klimstra, D.; Ghossein, R.; Katabi, N. (Feb 2019). "Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall.". Am J Surg Pathol. doi:10.1097/PAS.0000000000001218. PMID 30789358.
  4. ↑ Dalin, MG.; Katabi, N.; Persson, M.; Lee, KW.; Makarov, V.; Desrichard, A.; Walsh, LA.; West, L. et al. (10 2017). "Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions.". Nat Commun 8 (1): 1197. doi:10.1038/s41467-017-01178-z. PMID 29084941.
  5. ↑ Thway, K.; Bown, N.; Miah, A.; Turner, R.; Fisher, C. (Jun 2015). "Rhabdoid Variant of Myoepithelial Carcinoma, with EWSR1 Rearrangement: Expanding the Spectrum of EWSR1-Rearranged Myoepithelial Tumors.". Head Neck Pathol 9 (2): 273-9. doi:10.1007/s12105-014-0556-2. PMID 24993038.
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