Myoepithelial carcinoma: Difference between revisions
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'''Myoepithelial carcinoma''', abbreviated '''MECA''' a rare malignant [[salivary gland]] tumour.<ref name=pmid25970687>{{Cite journal | last1 = Kong | first1 = M. | last2 = Drill | first2 = EN. | last3 = Morris | first3 = L. | last4 = West | first4 = L. | last5 = Klimstra | first5 = D. | last6 = Gonen | first6 = M. | last7 = Ghossein | first7 = R. | last8 = Katabi | first8 = N. | title = Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases. | journal = Am J Surg Pathol | volume = 39 | issue = 7 | pages = 931-8 | month = Jul | year = 2015 | doi = 10.1097/PAS.0000000000000452 | PMID = 25970687 }}</ref> It is the malignant counterpart of [[myoepithelioma]]. | '''Myoepithelial carcinoma''', abbreviated '''MECA''' a rare malignant [[salivary gland]] tumour.<ref name=pmid25970687>{{Cite journal | last1 = Kong | first1 = M. | last2 = Drill | first2 = EN. | last3 = Morris | first3 = L. | last4 = West | first4 = L. | last5 = Klimstra | first5 = D. | last6 = Gonen | first6 = M. | last7 = Ghossein | first7 = R. | last8 = Katabi | first8 = N. | title = Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases. | journal = Am J Surg Pathol | volume = 39 | issue = 7 | pages = 931-8 | month = Jul | year = 2015 | doi = 10.1097/PAS.0000000000000452 | PMID = 25970687 }}</ref> | ||
It is the malignant counterpart of [[myoepithelioma]] and also known as '''malignant myoepithelioma'''.<ref name=pmid9797738>{{Cite journal | last1 = McCluggage | first1 = WG. | last2 = Primrose | first2 = WJ. | last3 = Toner | first3 = PG. | title = Myoepithelial carcinoma (malignant myoepithelioma) of the parotid gland arising in a pleomorphic adenoma. | journal = J Clin Pathol | volume = 51 | issue = 7 | pages = 552-6 | month = Jul | year = 1998 | doi = | PMID = 9797738 }}</ref> | |||
==General== | ==General== | ||
*Rare. | *Rare. | ||
*Often misdiagnosed as "benign".<ref name=pmid30789358/> | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid30789358>{{Cite journal | last1 = Xu | first1 = B. | last2 = Mneimneh | first2 = W. | last3 = Torrence | first3 = DE. | last4 = Higgins | first4 = K. | last5 = Klimstra | first5 = D. | last6 = Ghossein | first6 = R. | last7 = Katabi | first7 = N. | title = Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall. | journal = Am J Surg Pathol | volume = | issue = | pages = | month = Feb | year = 2019 | doi = 10.1097/PAS.0000000000001218 | PMID = 30789358 }}</ref> | ||
*Myoepithelial cells - may be cytologically very bland. | *Myoepithelial cells - may be cytologically very bland. | ||
*Hypocellular centre (hyaline or myxoid) and hypercellular periphery. | *Hypocellular centre (hyaline or myxoid) and hypercellular periphery. | ||
*Pushing border ("expansile nodular lobulated pattern"). | |||
*No ductal structures. | *No ductal structures. | ||
Note: | |||
*Overt features of malignancy (necrosis, nuclear atypia, infiltrative growth, proliferation) absent. | |||
DDx: | DDx: | ||
| Line 19: | Line 25: | ||
==Molecular== | ==Molecular== | ||
*Fusions with PLAG1.<ref name=pmid29084941>{{Cite journal | last1 = Dalin | first1 = MG. | last2 = Katabi | first2 = N. | last3 = Persson | first3 = M. | last4 = Lee | first4 = KW. | last5 = Makarov | first5 = V. | last6 = Desrichard | first6 = A. | last7 = Walsh | first7 = LA. | last8 = West | first8 = L. | last9 = Nadeem | first9 = Z. | title = Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions. | journal = Nat Commun | volume = 8 | issue = 1 | pages = 1197 | month = 10 | year = 2017 | doi = 10.1038/s41467-017-01178-z | PMID = 29084941 }}</ref> | *+/-Fusions with PLAG1 gene.<ref name=pmid29084941>{{Cite journal | last1 = Dalin | first1 = MG. | last2 = Katabi | first2 = N. | last3 = Persson | first3 = M. | last4 = Lee | first4 = KW. | last5 = Makarov | first5 = V. | last6 = Desrichard | first6 = A. | last7 = Walsh | first7 = LA. | last8 = West | first8 = L. | last9 = Nadeem | first9 = Z. | title = Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions. | journal = Nat Commun | volume = 8 | issue = 1 | pages = 1197 | month = 10 | year = 2017 | doi = 10.1038/s41467-017-01178-z | PMID = 29084941 }}</ref> | ||
*+/-EWSR1 gene rearrangement.<ref>{{Cite journal | last1 = Thway | first1 = K. | last2 = Bown | first2 = N. | last3 = Miah | first3 = A. | last4 = Turner | first4 = R. | last5 = Fisher | first5 = C. | title = Rhabdoid Variant of Myoepithelial Carcinoma, with EWSR1 Rearrangement: Expanding the Spectrum of EWSR1-Rearranged Myoepithelial Tumors. | journal = Head Neck Pathol | volume = 9 | issue = 2 | pages = 273-9 | month = Jun | year = 2015 | doi = 10.1007/s12105-014-0556-2 | PMID = 24993038 }}</ref> | |||
==See also== | ==See also== | ||