Difference between revisions of "P53"
Jump to navigation
Jump to search
(create) |
Jensflorian (talk | contribs) (→Interpretation: +neuropathology) |
||
| (5 intermediate revisions by one other user not shown) | |||
| Line 1: | Line 1: | ||
'''p53''' | {{ Infobox immunostain | ||
| Name = {{PAGENAME}} | |||
| Image = Anaplastic_astrocytoma_-_p53_-_very_high_mag.jpg | |||
| Width = | |||
| Caption = p53 staining in an [[anaplastic astrocytoma]]. | |||
| Abbrev = | |||
| Synonyms = | |||
| Similar = | |||
| Clones = | |||
| Use = cancer versus benign, prognostication | |||
| Subspecial = | |||
| Pattern = | |||
| Positive = nuclear staining (>60% or completely negative - see ''interpretation'') | |||
| Negative = | |||
| Other = | |||
}} | |||
'''p53''' marks a [[tumour suppressor]] protein commonly implicated in [[cancer]] and a common [[immunostain]]. | |||
==Interpretation== | |||
*p53 may be one of the most misinterpreted stains. | |||
**TP53 mutations are associated with >60% staining and no staining (0% of cell labelled).<ref name=pmid21552211 >{{Cite journal | last1 = Yemelyanova | first1 = A. | last2 = Vang | first2 = R. | last3 = Kshirsagar | first3 = M. | last4 = Lu | first4 = D. | last5 = Marks | first5 = MA. | last6 = Shih | first6 = IeM. | last7 = Kurman | first7 = RJ. | title = Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and nucleotide sequencing analysis. | journal = Mod Pathol | volume = 24 | issue = 9 | pages = 1248-53 | month = Sep | year = 2011 | doi = 10.1038/modpathol.2011.85 | PMID = 21552211 }}</ref> | |||
*Reliable interpretation of p53 may require co-assesment of other markers. | |||
**In neuropathology strong p53 expression in combination with loss of [[ATRX]] nuclear expression may allow one to skip the otherwise needed LOH 1p/19q testing in diffuse gliomas.<ref>{{Cite journal | last1 = Louis | first1 = DN. | last2 = Giannini | first2 = C. | last3 = Capper | first3 = D. | last4 = Paulus | first4 = W. | last5 = Figarella-Branger | first5 = D. | last6 = Lopes | first6 = MB. | last7 = Batchelor | first7 = TT. | last8 = Cairncross | first8 = JG. | last9 = van den Bent | first9 = M. | title = cIMPACT-NOW update 2: diagnostic clarifications for diffuse midline glioma, H3 K27M-mutant and diffuse astrocytoma/anaplastic astrocytoma, IDH-mutant. | journal = Acta Neuropathol | volume = | issue = | pages = | month = Mar | year = 2018 | doi = 10.1007/s00401-018-1826-y | PMID = 29497819 }}</ref> | |||
==See also== | ==See also== | ||
*[[Molecular pathology]]. | *[[Molecular pathology]]. | ||
*[[Li-Fraumeni syndrome]]. | |||
==References== | ==References== | ||
Latest revision as of 09:09, 21 March 2018
| P53 | |
|---|---|
| Immunostain in short | |
 p53 staining in an anaplastic astrocytoma. | |
| Use | cancer versus benign, prognostication |
| Positive | nuclear staining (>60% or completely negative - see interpretation) |
p53 marks a tumour suppressor protein commonly implicated in cancer and a common immunostain.
Interpretation
- p53 may be one of the most misinterpreted stains.
- TP53 mutations are associated with >60% staining and no staining (0% of cell labelled).[1]
- Reliable interpretation of p53 may require co-assesment of other markers.
See also
References
- ↑ Yemelyanova, A.; Vang, R.; Kshirsagar, M.; Lu, D.; Marks, MA.; Shih, IeM.; Kurman, RJ. (Sep 2011). "Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and nucleotide sequencing analysis.". Mod Pathol 24 (9): 1248-53. doi:10.1038/modpathol.2011.85. PMID 21552211.
- ↑ Louis, DN.; Giannini, C.; Capper, D.; Paulus, W.; Figarella-Branger, D.; Lopes, MB.; Batchelor, TT.; Cairncross, JG. et al. (Mar 2018). "cIMPACT-NOW update 2: diagnostic clarifications for diffuse midline glioma, H3 K27M-mutant and diffuse astrocytoma/anaplastic astrocytoma, IDH-mutant.". Acta Neuropathol. doi:10.1007/s00401-018-1826-y. PMID 29497819.